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ChemicalBook >> CAS DataBase List >>(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid

(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid

(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid Structure
(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid structure
CAS No.
863971-44-2
Chemical Name:
(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
Synonyms
(5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid;FMOC-3AA-OH;Fmoc-3AA-orl;Fmoc-3vvd-OH;4-[(2-{2-[(9H;Tripeptide (MMAE-3);Fmoc-MeVal-Val-Dil-OH;Fmoc-Meval-val-dolaisoleucine-OH;Fmoc-3vvd-OH （Fmoc-MeVal-Val-Dil-OH）;Inhibitor,antibody-drug,ADC,FMOC3VVDOH,ADC Linkers,non-cleavable,inhibit,conjugates,Antibody-drug conjugates linkers,FMOC 3VVD OH
CBNumber:
CB62715760
Molecular Formula:
C36H51N3O7
Molecular Weight:
637.81
MDL Number:
MFCD28386982
MOL File:
863971-44-2.mol
Last updated:2024-07-02 08:55:13
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(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid Properties

Boiling point 793.0±60.0 °C(Predicted)
Density 1.144±0.06 g/cm3(Predicted)
solubility DMSO: ≥ 37 mg/mL (58.01 mM)
pka 4.08±0.10(Predicted)
form Solid
color White to off-white
Water Solubility Water: < 0.1 mg/mL (insoluble)
InChIKey JDMOCVJBADMSJP-FCUBIXSHSA-N
SMILES C(NC(=O)[C@H](C(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C)(=O)[C@H](C(C)C)N([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C
FDA UNII 46H5G5LP2T

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-M2761 Fmoc-3VVD-OH ≥99.0% 863971-44-2 500mg $2500 2021-12-16 Buy
Product number Packaging Price Buy
CS-M2761 500mg $2500 Buy

(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid Chemical Properties,Uses,Production

Uses

Fmoc-3VVD-OH is a cleavable ADC linker for antibody-drug conjugate (ADC) synthesis.

Biological Activity

Fmoc-3VVD-OH is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

in vivo

ADCs consist of antibodies linked to ADC cytotoxins through ADC linkers.

target

Cleavable

(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid Suppliers

Global( 82)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemExpress
+86-021-58950125 info@chemexpress.com China 595 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21675 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10260 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12962 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30253 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10522 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3149 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19915 58
Supplier Advantage
ChemExpress
58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Hangzhou Huarong Pharm Co., Ltd. 		58
Nextpeptide Inc 		58
(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid Fmoc-3AA-orl FMOC-3AA-OH Fmoc-3vvd-OH Tripeptide (MMAE-3) Fmoc-Meval-val-dolaisoleucine-OH L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-L- valinamide (5S,8S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid (5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid Fmoc-MeVal-Val-Dil-OH Inhibitor,antibody-drug,ADC,FMOC3VVDOH,ADC Linkers,non-cleavable,inhibit,conjugates,Antibody-drug conjugates linkers,FMOC 3VVD OH 4-[(2-{2-[(9H Fmoc-3vvd-OH （Fmoc-MeVal-Val-Dil-OH） 863971-44-2 ADCs Linkers ADCs ADC LINKER