ChemicalBook >> CAS DataBase List >>GDC-0994
GDC-0994
- CAS No.
- 1453848-26-4
- Chemical Name:
- GDC-0994
- Synonyms
- CS-1841;RG-7842);GDC-0994;EOS-60648;Ravoxertinib;GDC-0994;RAVOXERTINIB;RAVOXERTINIB (GDC-0994);GDC 0994;GDC-0994;GDC0994;GDC-0994 (RAVOXERTINIB, RG7842);1-(1S)-1-(3-Fluoro-4-chlorophenyl)-2-hydroxyethyl-4-2-(1-methyl-1H-pyrazol-5-yl)aminopyrimidin-4-yl-2(1H)-pyridinone
- CBNumber:
- CB62716237
- Molecular Formula:
- C21H18ClFN6O2
- Molecular Weight:
- 440.86
- MDL Number:
- MFCD28143918
- MOL File:
- 1453848-26-4.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:13
| Boiling point | 734.6±70.0 °C(Predicted) |
|---|---|
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥44.1 mg/mL in DMSO; insoluble in H2O; ≥19.2 mg/mL in EtOH |
| form | solid |
| pka | 14.03±0.10(Predicted) |
| color | White to yellow |
| FDA UNII | R6AXV96CRH |
| NCI Drug Dictionary | ravoxertinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
GDC-0994 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21107 | GDC-0994 ≥98% | 1453848-26-4 | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21107 | GDC-0994 ≥98% | 1453848-26-4 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 21107 | GDC-0994 ≥98% | 1453848-26-4 | 5mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 21107 | GDC-0994 ≥98% | 1453848-26-4 | 10mg | $426 | 2024-03-01 | Buy |
| TRC | G299910 | GDC-0994 | 1453848-26-4 | 2.5mg | $1105 | 2021-12-16 | Buy |
GDC-0994 Chemical Properties,Uses,Production
Description
GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively. It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.
Uses
GDC-0994 is a potent and orally available ERK12 inhibitor shown to prevent ERK-dependant tumor cell proliferation and survival.
References
[1]. robarge k, schwarz j, blake j, et al. abstract ddt02-03: discovery of gdc-0994, a potent and selective erk1/2 inhibitor in early clinical development. aacr annual meeting, 2014, san diego, ca.
GDC-0994 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 110)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
GDC-0994
(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one GDC-0994
(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-2(1H)-pyridinone
Ravoxertinib
GDC 0994;GDC-0994;GDC0994
CS-1841
GDC-0994;RAVOXERTINIB
RAVOXERTINIB (GDC-0994)
2(1H)-Pyridinone, 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-
RG-7842)
EOS-60648
1-(1S)-1-(3-Fluoro-4-chlorophenyl)-2-hydroxyethyl-4-2-(1-methyl-1H-pyrazol-5-yl)aminopyrimidin-4-yl-2(1H)-pyridinone
GDC-0994 (RAVOXERTINIB, RG7842)
1453848-26-4
C21H18ClFN6O2
Inhibitors