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LSN2814617
- CAS No.
- 1313498-08-6
- Chemical Name:
- LSN2814617
- Synonyms
- LSN2814617;LSN2814617 racemate;1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethy;3-(1,1-Dimethylethyl)-7-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridine;1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-7-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-5,6,7,8-tetrahydro-
- CBNumber:
- CB62728744
- Molecular Formula:
- C18H20FN5O
- Molecular Weight:
- 341.38
- MDL Number:
- MOL File:
- 1313498-08-6.mol
- MSDS File:
- SDS
Last updated:2023-05-21 10:59:17
LSN2814617 Chemical Properties,Uses,Production
Biological Activity
LSN2814617 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5).1 It potentiates glutamate-induced calcium mobilization in MCB3901 cells expressing human mGluR5 (EC50 = 52 nM). LSN2814617 increases rat hippocampal mGluR5 receptor occupancy (ED50 = 13 mg/kg). It increases wakefulness and decreases non-rapid eye movement (NREM) and REM sleep in rats when administered at doses of 0.3, 1, and 3 mg/kg.
References
1.Gilmour, G., Broad, L.M., Wafford, K.A., et al.In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the ratNeuropharmacology64224-239(2013)
LSN2814617 Preparation Products And Raw materials
Raw materials
Preparation Products
LSN2814617 Suppliers
Global( 22)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Shanghai joygo pharmacetical tech., Co., Ltd. | 13621615409 | sale1@joygooo.com | China | 109 | 50 |
| D&C Chemicals | +86-21-58447131 | 1724405207@qq.com | China | 472 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1720 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
LSN2814617
LSN2814617 racemate
1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethy
3-(1,1-Dimethylethyl)-7-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridine
1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-7-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-5,6,7,8-tetrahydro-
1313498-08-6