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SIM010603

SIM010603 Structure
SIM010603 structure
CAS No.
1032265-67-0
Chemical Name:
SIM010603
Synonyms
SIM010603;SIM 010603; SIM-010603;1H-Indole-3-carboxamide, N-[2-(dimethylamino)ethyl]-7-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-2-methyl-, (7Z)-
CBNumber:
CB62731137
Molecular Formula:
C22H25FN4O2
Molecular Weight:
396.46
MDL Number:
MOL File:
1032265-67-0.mol
Last updated:2024-10-28 16:48:35
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SIM010603 Properties

Boiling point 602.7±55.0 °C(Predicted)
Density 1.294±0.06 g/cm3(Predicted)
pka 11.68±0.20(Predicted)

SIM010603 Chemical Properties,Uses,Production

Description

SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.

SIM010603 Preparation Products And Raw materials

Raw materials

Preparation Products

SIM010603 Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19863 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19711 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from SIM010603 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SIM010603 pictures 2024-10-28 SIM010603
1032265-67-0
 US $1820.00-3100.00 / mg 10g TargetMol Chemicals Inc.
  • SIM010603 pictures
  • SIM010603
    1032265-67-0
  • US $1820.00-3100.00 / mg
  • TargetMol Chemicals Inc.
SIM010603 SIM 010603; SIM-010603 1H-Indole-3-carboxamide, N-[2-(dimethylamino)ethyl]-7-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-2-methyl-, (7Z)- 1032265-67-0