ChemicalBook >> CAS DataBase List >>1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE

1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE

1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE structure

CAS No.: 105431-72-9

Chemical Name:: 1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE

Synonyms: linopiridine;Linopirdine2HCl;LINOPIRDINE (DUP996);LINOPIRDINE DIHYDROCHLORIDE;1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one;1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one;1-Phenyl-3,3-bis(4-pyridinylmethyl)-2,3-dihydro-1H-indole-2-one;2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-;1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride;1-phenyl-3,3-bis[(pyridin-4-yl)methyl]-2,3-dihydro-1H-indol-2-one

CBNumber:: CB6283722

Molecular Formula:: C26H21N3O

Molecular Weight:: 391.46

MDL Number:: MFCD06245587

MOL File:: 105431-72-9.mol

Last updated:2024-11-19 15:53:33

Request For Quotation

1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE Properties

Melting point	186-186.5 °C
Boiling point	655.9±50.0 °C(Predicted)
Density	1?+-.0.06 g/cm3(Predicted)
storage temp.	Desiccate at RT
solubility	DMSO: >10mg/mL
pka	6.01±0.10(Predicted)
form	A crystalline solid
color	white to off-white
FDA UNII	I5TB3NZ94T

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
WGK Germany	3

1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	L134	Linopirdine ≥98% (HPLC)	105431-72-9	10mg	$229	2024-03-01	Buy
Sigma-Aldrich	L134	Linopirdine ≥98% (HPLC)	105431-72-9	50mg	$915	2024-03-01	Buy
Cayman Chemical	19547	Linopirdine	105431-72-9	1mg	$32	2024-03-01	Buy
Cayman Chemical	19547	Linopirdine	105431-72-9	5mg	$121	2024-03-01	Buy
Cayman Chemical	19547	Linopirdine	105431-72-9	10mg	$195	2024-03-01	Buy

Product number	Packaging	Price	Buy
L134	10mg	$229	Buy
L134	50mg	$915	Buy
19547	1mg	$32	Buy
19547	5mg	$121	Buy
19547	10mg	$195	Buy

1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE Chemical Properties,Uses,Production

Description

Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; K_v7.2/7.3; KCNQ2/3) K⁺ current with an IC₅₀ value of 2.4 μM. Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca²⁺ influx and increased neurotransmitter release. Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory. Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC₅₀ = 115 μM in HEK293 cells voltage clamped at -60 mV).

Uses

Alzheimer’s disease treatment (cognition enhancer).

Definition

ChEBI: Linopirdine is a member of indoles.

Biological Activity

Blocker of KCNQ voltage-gated potassium channels; blocks KCNQ2+3/M-currents (IC 50 = 4-7 μ M) and KCNQ1 homomeric channels (IC 50 = 8.9 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .

1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE Suppliers

Global( 46)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42958	64
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4566	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60

Supplier	Advantage
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
VDM Biochemicals	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Lollane Biological Technology Co.,Ltd.	55
EMMX Biotechnology LLC	60

View Lastest Price from 1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Linopirdine 105431-72-9	US $36.00-80.00 / mg		99.78%	10g	TargetMol Chemicals Inc.

Linopirdine
105431-72-9
US $36.00-80.00 / mg
99.78%
TargetMol Chemicals Inc.

105431-72-9(1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE)Related Search:

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 1,3-DIMETHYLINDOLIN-2-ONE 4-PYRIDINEPROPANAMINE 4-(2-aminophenethyl)pyridine 4-Pyridinepropanamine,beta-methyl-,(betaS)-(9CI)

4-Pyridinepropanamine,beta-methyl-,(betaR)-(9CI) N1,N1-DIMETHYL-3-(4-PYRIDYL)PROPAN-1-AMINE 1-PHENYL-2,3-DIHYDRO-1H-INDOLE 3-Pyridinepropanamine dihydrochloride 4,4'-Trimethylenedipyridine

4-PYRIDINEPROPANAMINE MONOHYDROCHLORIDE 4-ISOBUTYL-PYRIDINE 1-Phenyloxindole 1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE 4-phenethylpyridine

3-METHYL-1-PHENYLINDOLIN-2-ONE

1of4

LINOPIRDINE DIHYDROCHLORIDE 1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE LINOPIRDINE (DUP996) Linopirdine2HCl DuP 996, 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one 1-Phenyl-3,3-bis(4-pyridinylmethyl)-2,3-dihydro-1H-indole-2-one 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one linopiridine 1,3-Dihydro-1-Phenyl-3,3-Bis(4-Pyridinylmethyl)-2H-Indol-2-One(WXC03502) 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)- 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one Kv7,enhancing,inhibit,DuP-996,TRP Channel,Inhibitor,Transient receptor potential channels,KcsA,current,acetylcholine,Channels,Linopirdine,DuP996,orally,Potassium Channel,TRPV1,KCNQ,M-type,cognition 1-phenyl-3,3-bis[(pyridin-4-yl)methyl]-2,3-dihydro-1H-indol-2-one 105431-72-9 C26H21N3O2HCl DuP 996 Pharmaceuticals Potassium channel