Amlexanox
- CAS No.
- 68302-57-8
- Chemical Name:
- Amlexanox
- Synonyms
- Aphthasol;Solf;Amlexanox RS;2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid;Elics;aa-673;NSC7223;CHX-3673;amoxanox;NSC 7223
- CBNumber:
- CB6294838
- Molecular Formula:
- C16H14N2O4
- Molecular Weight:
- 298.29
- MDL Number:
- MFCD00864790
- MOL File:
- 68302-57-8.mol
| Melting point | >3000C |
|---|---|
| Boiling point | 570.0±50.0 °C(Predicted) |
| Density | 1.408±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL at warmed, clear |
| pka | 3.95±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Merck | 14,490 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 68302-57-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | BRL1C2459K |
| ATC code | A01AD07,R03DX01 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-43 | |||||||||
| Safety Statements | 36/37-37-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DJ3102000 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
Amlexanox price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0517 | Amlexanox ≥98% (HPLC) | 68302-57-8 | 10mg | $105 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0517 | Amlexanox ≥98% (HPLC) | 68302-57-8 | 50mg | $421 | 2024-03-01 | Buy |
| TCI Chemical | A2401 | Amlexanox >98.0%(HPLC)(T) | 68302-57-8 | 1g | $58 | 2024-03-01 | Buy |
| TCI Chemical | A2401 | Amlexanox >98.0%(HPLC)(T) | 68302-57-8 | 5g | $165 | 2024-03-01 | Buy |
| Cayman Chemical | 14181 | Amlexanox ≥98% | 68302-57-8 | 1g | $92 | 2024-03-01 | Buy |
Amlexanox Chemical Properties,Uses,Production
Description
Amlexanox is an orally-active antiasthmatic agent useful in the treatment of bronchial asthma and allergy-related sinus disorders. The therapeutic effect of amlexanox appears to be attributed to its inhibitory actions on leukohiene D4, PAF and histamine.
Chemical Properties
White Crystalline Solid
Originator
Takeda (Japan)
Uses
Inhibits release of allergic mediators from mast cells. Antiallergic; antiasthmatic
Definition
ChEBI: A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Manufacturing Process
A mixture of 2 ml of morpholine, 3 ml of dimethylformamide and 10 ml of water was heated to 60°C and under stirring the equal molecular quantity of 6-isopropyl-4-oxo-4H-1-benzopyran-3-carbonitrile was added for 5 minutes. The mixture was heated at that temperature for one hour and the resultant precipitate was filtered, rained with water recrystallized from acetic acid and washed with chloroform. By the above procedure was obtained 2-amino-6- isopropyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde melting at 206°-208°C. A mixture of 4 ml ethyl cyanoacetate, 50 ml of ethanol, 5 ml of piperidine and the equal molecular quantity of 2-amino-6-isopropyl-4-oxo-4H-1-benzopyran- 3-carboxaldehyde was refluxed for 30 minutes and, after cooling, the crystalline precipitate was filtered and washed with chloroform. By above procedure was obtained ethyl-2-amino-7-isopropyl-1-azaxanthone-3- carboxylate, melting after recrystallization from ethanol at 243°-244°C. A mixture of 10 ml of acetic acid and 10 ml of 55% sulfuric acid the equal molecular quantity and 2-ethyl-amino-7-isopropyl-1-azaxanthone-3- carboxylate was stirred at 130°C for 4 hours and, after water was added, the precipitate was collected by filtration and recrystalllized from dimethylformamide to give the 2-amino-7-(1-methylethyl)-5-oxo-5H- [1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, melting point 300°C.
brand name
Aphthasol (Uluru);Solfa.
Therapeutic Function
Antiulcer (topical)
General Description
Amlexanox is an anti-allergic drug with anti-inflammatory properties.
Biochem/physiol Actions
Amlexanox elevates the amount of nonsense-containing mRNAs in treated cells and helps to generate full-length proteins effectively.
storage
Store at -20°C
References
1) Koch et al. (2013), Obesity: Teaching an old drug new tricks – amlexanox targets inflammation to improve metabolic dysfunction; Nat. Rev. Endocrinol., 9 185 2) Reilly et al. (2013), An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice; Nat. Med., 19 313 3) Nasry et al. (2016), Different modalities for treatment of recurrent aphthous stromatitis. A Randomized clinical trial; J. Clin. Exp. Dent. 8 e517 4) Cheng et al. (2018), Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKε/TBK1/NFκB signaling; Theranostics 8 4633
Amlexanox Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3883 | 58 |
| Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 | info@millionpharm.com | China | 294 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from Amlexanox manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | Amlexanox
68302-57-8
|
US $1.00-1.00 / kg | 0.0001kg | 99.9% | 200kg | Jinan Million Pharmaceutical Co., Ltd | |
 |
2025-04-28 | Amlexanox
68302-57-8
|
US $0.00-0.00 / Kg/Bag | 100g | 99.0%~101.0% | 700kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-03-21 | Aphthasol
68302-57-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd |