2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine
![2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine Structure](CAS/20200401/GIF/459147-39-8.gif)
- CAS No.
- 459147-39-8
- Chemical Name:
- 2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine
- Synonyms
- CS-1608;SW033291;SW033291(SW-033291);SW033291 >=98% (HPLC);SW033291, 10 mM in DMSO;SW033291;SW-033291;SW033291;SW 033291;2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine;2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridin-3-amine;Thieno[2,3-b]pyridin-3-amine, 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)-;4-phenyl-6-(thiophen-2-yl)-2-thioxo-1,2- dihydropyridine-3-carbonitrile
- CBNumber:
- CB63035399
- Molecular Formula:
- C21H20N2OS3
- Molecular Weight:
- 412.59
- MDL Number:
- MFCD02973087
- MOL File:
- 459147-39-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| NFPA 704 |
|
2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1485 | SW033291 ≥98% (HPLC) | 459147-39-8 | 5mg | $182 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1485 | SW033291 ≥98% (HPLC) | 459147-39-8 | 25mg | $582 | 2024-03-01 | Buy |
| Cayman Chemical | 18040 | SW033291 ≥95% | 459147-39-8 | 1mg | $45 | 2024-03-01 | Buy |
| Cayman Chemical | 18040 | SW033291 ≥95% | 459147-39-8 | 5mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 18040 | SW033291 ≥95% | 459147-39-8 | 10mg | $220 | 2024-03-01 | Buy |
2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine Chemical Properties,Uses,Production
Uses
SW033291 is an inhibitor which maintains the ability to promote tissue regeneration through inhibition of prostaglandin-degrading enzyme 15-PGDH.
Biological Activity
SW033291 is an inhibitor of the prostaglandin-degrading enzyme 15-PGDH. PGE2 is known to promote hematopoiesis and to promote reeneration by causing stem cells to proliferate. 15-PGDH degrades prostaglandin PGE2 and is a negative regulator of tissue regeneration and repair. SW033291 inhibition of 15-PGDH doubled levels of PGE2 and doubled rates of colon and liver tissue regeneration. Mice given SW033291 after receiving a bone marrow transplant had a two- to threefold increase in the number of donor cells th at homed to the their bone marrow.
in vivo
SW033291 (10 mg/kg; intraperitoneal injection; twice daily; for 3 days; C57BL/6J mice) treatment for three consecutive days shows significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells[1].
| Animal Model: | C57BL/6J mice[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; twice daily; for 3 days ( for 5 doses) |
| Result: | Showed significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells. |
storage
Store at -20°C
2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12186 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
