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4-Hydroxypyridine

4-Hydroxypyridine structure

CAS No.: 626-64-2

Chemical Name:: 4-Hydroxypyridine

Synonyms: PYRIDIN-4-OL;4-PYRIDINOL;4HYDROXYPRIDINE;4-Hydroxypyride;1H-Pyridin-4-ol;Compound Fr14055;4-HYDROXYPYRIDINE;TIMTEC-BB SBB000030;4-hydroxyl pyridine; 4-Hydroxypyridone

CBNumber:: CB6303828

Molecular Formula:: C5H5NO

Molecular Weight:: 95.1

MDL Number:: MFCD00006419

MOL File:: 626-64-2.mol

MSDS File:: SDS

Last updated:2024-11-11 14:08:43

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4-Hydroxypyridine Properties

Melting point	150-151 °C (lit.)
Boiling point	230-235 °C/12 mmHg (lit.)
Density	1.1418 (rough estimate)
refractive index	1.5939 (estimate)
Flash point	221 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Powder or Chunks
pka	3.2(at 20℃)
color	Beige to light brown
Water Solubility	Soluble
BRN	105800
InChIKey	GCNTZFIIOFTKIY-UHFFFAOYSA-N
LogP	-1.300 (est)
CAS DataBase Reference	626-64-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	3P2MV07G53
NIST Chemistry Reference	4-Pyridinol(626-64-2)
EPA Substance Registry System	4-Pyridinol (626-64-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P261-P280-P305+P351+P338

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-41-37/38-22

Safety Statements

26-36-37/39-39

WGK Germany

RTECS

UU7701450

3-8-10

Hazard Note

Harmful/Irritant

TSCA

Yes

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
3		1

4-Hydroxypyridine price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	120618	4-Hydroxypyridine 95%	626-64-2	25g	$66.8	2024-03-01	Buy
Sigma-Aldrich	120618	4-Hydroxypyridine 95%	626-64-2	100g	$184	2024-03-01	Buy
Sigma-Aldrich	CDS013613	4-hydroxypyridine AldrichCPR	626-64-2	1G	$68.1	2023-06-20	Buy
TCI Chemical	H0332	4-Hydroxypyridine >99.0%(GC)	626-64-2	25g	$80	2024-03-01	Buy
Alfa Aesar	A14586	4-Hydroxypyridine, 97%	626-64-2	25g	$54.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
120618	25g	$66.8	Buy
120618	100g	$184	Buy
CDS013613	1G	$68.1	Buy
H0332	25g	$80	Buy
A14586	25g	$54.65	Buy

4-Hydroxypyridine Chemical Properties,Uses,Production

Description

4-Hydroxypyridine, available from pyridylpyridinium chloride hydrochloride, is the substrate for diodone and its n-propyl ester, propyliodone. 4-Hydroxypyridine (4-HP) is a non-nucleophilic analog of the product phenol found to bind specifically to and stabilize the aminoacrylate intermediate. When 4-HP is added to Tyrosine phenol-lyase (TPL) reactions, an absorption peak at 340 nm is observed. The formation of the 340 nm peak correlates with the decay of the quinonoid intermediate peak at 505 nm, with a clean isosbestic point, and the observed rate constants show an inverse dependence on the concentration of 4-HP. These results confirm that the observed peak at 340 nm is due to the formation of the amino acrylate intermediate[1-2].

Chemical Properties

Beige crystalline powder

Uses

4-Hydroxypyridine was used in the synthesis of (Ag₃MoO₃F₃) (Ag₃MoO₄)Cl by hydro(solvato)thermal methods. It was used as model compound to study the natural photodegradation of representative aquatic environmental contaminants.

Definition

ChEBI: A monohydroxypyridine that is pyridine in which the hydrogen at position 4 has been replaced by a hydroxy group.

Purification Methods

Crystallise 4-pyridone from H2O or wet CHCl3 as the monohydrate. It loses H2O on drying in vacuo over H2SO4. Store it over KOH because it is hygroscopic.[Beilstein 21 III/IV 446, 21/7 V 152.]

References

[1] Yates, F. S. “2.09 – Pyridines and their Benzo Derivatives: (vi) Applications.”Comprehensive Heterocyclic Chemistry 2 (1984): 511-524.
[1] Robert S Phillips, Olivia Bauer. “Characterization of aminoacrylate intermediates of pyridoxal-5’-phosphate dependent enzymes.” Methods in enzymology 685 (2023): 199–224.

4-Hydroxypyridine synthesis

Synthesis of 4-Hydroxypyridine from Pyridine-4-boronic acid

4-Hydroxypyridine Preparation Products And Raw materials

Raw materials

4-ALLYLOXYPYRIDINE 4-Methoxypyridine 4-(BENZYLOXY)PYRIDINE 4-HYDROXYPYRIDINE-1-OXIDE N-(4-Pyridyl)pyridinium chloride hydrochloride

4-Iodopyridine 2,3-DIMETHYL-1,3-BUTADIENE Pyridine-4-boronic acid

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Preparation Products

2,4-DICHLORO-5-NITROPYRIDINE 3-AMINO-4-METHOXYPYRIDINE 3,4-Diaminopyridine 4-Dimethylaminopyridine 4-Chloro-3-nitropyridine

3,4,5-TRIBROMOPYRIDINE 2,3,4,5,6-PENTABROMOPYRIDINE 4-Amino-3-nitropyridine 3,5-DibroMo-4-Methoxy-pyridine 4-chloropyridine

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4-Hydroxypyridine Suppliers

Global( 612)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Dexinjia Bio&Tech Co., Ltd	+86-0531-82375893 +86-15064117275	sales@jndxj.com	China	1267	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8811	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12839	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	7514	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20287	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55

Supplier	Advantage
Jinan Dexinjia Bio&Tech Co., Ltd	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Shanghai UCHEM Inc.	58
Henan Fengda Chemical Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Nanjing Finetech Chemical Co., Ltd.	55

View Lastest Price from 4-Hydroxypyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	4-Hydroxypyridine 626-64-2	US $0.00 / Kg/Drum	1KG	98%min	1000kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-11	4-Hydroxypyridine 626-64-2	US $1.00 / KG	1KG	99%	10 mt	Hebei Weibang Biotechnology Co., Ltd
2024-11-01	4-Hydroxypyridine 626-64-2	US $225.00 / kg	1kg	0.97	25kg	Shanghai UCHEM Inc.

4-Hydroxypyridine
626-64-2
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

4-Hydroxypyridine
626-64-2
US $1.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

4-Hydroxypyridine
626-64-2
US $225.00 / kg
0.97
Shanghai UCHEM Inc.

4-Hydroxypyridine Spectrum

4-Hydroxypyridine(626-64-2)MS 4-Hydroxypyridine(626-64-2)¹HNMR 4-Hydroxypyridine(626-64-2)¹³CNMR 4-Hydroxypyridine(626-64-2)IR1 4-Hydroxypyridine(626-64-2)IR2 4-Hydroxypyridine(626-64-2)Raman

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2-Chloro-4-hydroxypyridine HYDROXYPYRIDINE(3-) 2-Bromo-4-Hydroxypyridine

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4-Hydroxypyridine, tech., 90% Hydroxypyridine(Gamma-) 4-Hydroxypyridine,97% 4-HYDROXYPYRIDINE TIMTEC-BB SBB000030 4-Hydroxypyride 4HYDROXYPRIDINE 4-HYDROXYPYRIDINE ( 4-PYRIDINOL ) 2-HYDROXY PYRIDINE PYRIDIN-2-OL 4-HYDROXY PYRIDINE PYRIDIN-4-OL 4-HYDROXYPYRIDINE pract 4-Pyridinol, 4-Pyridone 1H-Pyridin-4-ol 4-Hydroxypyridine,95% 4-Hydroxypyridine,98% 4-Hydroxypyridine, 95% 100GR 4-Hydroxypyridine, 95% 25GR 4-Hydroxypyridine 95% 4-hydroxyl pyridine 4-oxo-1,4-dihydropyridine 7-Hydroxypyrazolo[1,5-a]pyrimidine-6-carbonitrile gamma-Hydroxypyridine 4-Hydroxypyridone 4-Hydroxypyridine> 4-Hydroxypyridine, for synthesis 4-Hydroxypyridine ISO 9001：2015 REACH bmk3 4-Hydroxypyridine 4-Hydroxypyridine practical grade, 95% PYRIDIN-4-OL 4-PYRIDINOL 4-Hydroxypyridine with lowest price Compound Fr14055 626-64-2 C5H4NO Building Blocks C5 Heterocyclic Building Blocks Pyridines Other series Pyridine Series Building Blocks C5 Chemical Synthesis Heterocyclic Building Blocks Pyridine Heterocyclic Compounds Pyridines bc0001 626-64-2