Bis-PEG6-NHS ester
- CAS No.
- 1526718-98-8
- Chemical Name:
- Bis-PEG6-NHS ester
- Synonyms
- BIS-PEG6-NHS;Di-NHS Ester-PEG6;Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate;4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber:
- CB63062418
- Molecular Formula:
- C24H36N2O14
- Molecular Weight:
- 576.55
- MDL Number:
- MFCD24539464
- MOL File:
- 1526718-98-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Bis-PEG6-NHS ester price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0107647 | Bis-PEG6-NHSester ≥97.0% | 1526718-98-8 | 100mg | $230 | 2021-12-16 | Buy |
| BroadPharm | BP-21681 | Bis-PEG6-NHSester 98% | 1526718-98-8 | 100mg | $250 | 2021-12-16 | Buy |
| BroadPharm | BP-21681 | Bis-PEG6-NHSester 98% | 1526718-98-8 | 500mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0107647 | Bis-PEG6-NHSester ≥97.0% | 1526718-98-8 | 250mg | $400 | 2021-12-16 | Buy |
| BroadPharm | BP-21681 | Bis-PEG6-NHSester 98% | 1526718-98-8 | 1g | $460 | 2021-12-16 | Buy |
Bis-PEG6-NHS ester Chemical Properties,Uses,Production
Description
Bis-PEG6-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Biological Activity
Bis-PEG6-NHS ester is a PROTAC bridge and belongs to the PEG class. It can be used to synthesize a range of PROTAC molecules. Also Bis-PEG6-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
Bis-PEG6-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13056 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10978 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
View Lastest Price from Bis-PEG6-NHS ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-25 | Bis-PEG6-NHS ester
1526718-98-8
|
US $0.00 / g | 5g | >98.00% | 5g | Xian confluore Biological Technology Co., Ltd. |
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- Bis-PEG6-NHS ester
1526718-98-8
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.