RAF709
- CAS No.
- 1628838-42-5
- Chemical Name:
- RAF709
- Synonyms
- RAF709;CS-2505;RAF-709;RAF 709;Inhibitor,inhibit,Raf,Raf kinases,RAF709,RAF-709,RAF 709;N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide;N-[2-Methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)benzamide;Benzamide, N-[2-methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)-
- CBNumber:
- CB63155071
- Molecular Formula:
- C28H29F3N4O4
- Molecular Weight:
- 542.55
- MDL Number:
- MFCD30534393
- MOL File:
- 1628838-42-5.mol
Boiling point | 622.7±55.0 °C(Predicted) |
---|---|
Density | 1.321±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility |
DMSO:100.0(Max Conc. mg/mL);184.31(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.61(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);55.29(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);184.31(Max Conc. mM) |
form | A crystalline solid |
pka | 11.87±0.70(Predicted) |
color | White to off-white |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H319-H335-H302+H312+H332-H315 |
Precautionary statements | P301+P312-P302+P352-P305+P351+P338 |
HS Code | 2934999090 |
RAF709 price More Price(12)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 23820 | RAF709 ≥98% | 1628838-42-5 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 23820 | RAF709 ≥98% | 1628838-42-5 | 5mg | $172 | 2024-03-01 | Buy |
Cayman Chemical | 23820 | RAF709 ≥98% | 1628838-42-5 | 10mg | $321 | 2024-03-01 | Buy |
AK Scientific | 3613EB | N-[6-Methyl-5-[5-morpholin-4-yl-6-(oxan-4-yloxy)pyridin-3-yl]pyridin-3-yl]-3-(trifluoromethyl)benzamide | 1628838-42-5 | 10mg | $455 | 2021-12-16 | Buy |
Axon Medchem | Axon2817 | RAF709 99% | 1628838-42-5 | 50mg | $462 | 2021-12-16 | Buy |
RAF709 Chemical Properties,Uses,Production
Description
RAF709 is a potent inhibitor of B-RAF and C-RAF (IC50s = 0.4 and 0.5 nM, respectively). It is selective for RAF kinases exhibiting >99% inhibition of only B-RAF, B-RAFV600E, and C-RAF in a panel of 456 kinases. However, DDR1, DDR2, FRK, and PDGFRβ are also inhibited by >80% at a concentration of 1 μM. RAF709 inhibits phosphorylation of MEK and ERK (EC50s = 0.02 and 0.1 μM, respectively) with minimal paradoxical activation, stabilizes BRAF-CRAF dimers (EC50 = 0.8 μM), and reduces proliferation of Calu-6 RAS mutant cells (EC50 = 0.95 μM). In a Calu-6 mouse non-small cell lung cancer (NSCLC) xenograft model, RAF709 (10-200 mg/kg) reduces ERK phosphorylation and decreases tumor volume in a dose-dependent manner without affecting total body weight.
RAF709 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9336 | 55 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |