Saroglitazar (Magnesium)
- CAS No.
- 1639792-20-3
- Chemical Name:
- Saroglitazar (Magnesium)
- Synonyms
- Saroglitazar Magnesiu;Saroglitazar D4 Mg Salt;Saroglitazar (Magnesium);Saroglitazar Magnesium, 10 mM in DMSO;magnesium (S)-2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate;(T-4)-Bis[(αS)-α-(ethoxy-κO)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-κO]magnesium
- CBNumber:
- CB63167634
- Molecular Formula:
- C50H56MgN2O8S2
- Molecular Weight:
- 901.43
- MDL Number:
- MFCD29075338
- MOL File:
- 1639792-20-3.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : 50 mg/mL (55.47 mM);Water : < 0.1 mg/mL (insoluble) |
| form | Solid |
| color | Off-white to light yellow |
| FDA UNII | K8V5DLS63R |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Saroglitazar (Magnesium) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6259 | SaroglitazarMagnesium 98.85% | 1639792-20-3 | 1mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-6259 | SaroglitazarMagnesium 98.85% | 1639792-20-3 | 5mg | $468 | 2021-12-16 | Buy |
| ChemScene | CS-6259 | SaroglitazarMagnesium 98.85% | 1639792-20-3 | 10mg | $720 | 2021-12-16 | Buy |
| ChemScene | CS-6259 | SaroglitazarMagnesium 98.85% | 1639792-20-3 | 25mg | $1440 | 2021-12-16 | Buy |
| ChemScene | CS-6259 | SaroglitazarMagnesium 98.85% | 1639792-20-3 | 50mg | $2160 | 2021-12-16 | Buy |
Saroglitazar (Magnesium) Chemical Properties,Uses,Production
Uses
Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.
Biological Activity
Potent and selective PPARα/γ agonist.
Saroglitazar is a potent and selective PPARα/γ (peroxisome proliferator-activated receptor) agonist th at exhibits lipid-lowering and insulin-sensitizing effects. Saroglitazar is approved in India for the treatment of diabetes type 2 and dyslipidemia.
in vivo
In db/db mice, 12-day treatment with Saroglitazar (0.01-3 mg/kg per day, orally) causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose. A 90-day repeated dose comparative study in Wistar rats and marmosets confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes[1].
IC 50
PPARα: 0.65 pM (EC50, HepG2 cell); PPARγ: 3 nM (EC50, HepG2 cell)
References
[1] Jain MR, et al. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering effects in preclinical models. Pharmacol Res Perspect. 2015 Jun;3(3):e00136. DOI:10.1002/prp2.136
Saroglitazar (Magnesium) Preparation Products And Raw materials
Raw materials
Preparation Products
Saroglitazar (Magnesium) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 485 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 | hanson@sdhanjiang.com | China | 339 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39003 | 58 |
| Guangzhou CATO Research Chemicals Inc. | +86-020-81960175-617 +8615602392859 | Intermediate@cato-chem.com | China | 6335 | 58 |
| Beijing Jingzi Pharmaceutical Technology Co., Ltd. | 15011485209 | 17241816@qq.com | China | 82 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 |
View Lastest Price from Saroglitazar (Magnesium) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-13 | Saroglitazar Magnesium
1639792-20-3
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | |
 |
2024-11-19 | Saroglitazar Magnesium
1639792-20-3
|
US $88.00-358.00 / mg | 98.1% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Saroglitazar Magnesium
1639792-20-3
|
US $88.00-358.00 / mg | 98.1% | 10g | TargetMol Chemicals Inc. |
-
- Saroglitazar Magnesium
1639792-20-3
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Saroglitazar Magnesium
1639792-20-3
- US $88.00-358.00 / mg
- 98.1%
- TargetMol Chemicals Inc.
-
- Saroglitazar Magnesium
1639792-20-3
- US $88.00-358.00 / mg
- 98.1%
- TargetMol Chemicals Inc.