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DECAMETHONIUM BROMIDE

DECAMETHONIUM BROMIDE structure

CAS No.: 541-22-0

Chemical Name:: DECAMETHONIUM BROMIDE

Synonyms: decacuran;syncurine;dekamethoniumbromid;DECAMETHONIUM BROMIDE;decamethoniumdibromide;Decamethonium Bromide >Decamethonium bromide ,98%;Decamethonium Bromide, ≥ 98.0%;DECAMETHONIUM BROMIDE USP/EP/BP;DECANE-1,10-BIS(TRIMETHYLAMMONIUM BROMIDE)

CBNumber:: CB6360047

Molecular Formula:: C16H38Br2N2

Molecular Weight:: 418.29

MDL Number:: MFCD00011779

MOL File:: 541-22-0.mol

MSDS File:: SDS

Last updated:2024-12-18 14:08:57

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DECAMETHONIUM BROMIDE Properties

Melting point	263-267 °C(lit.)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMF: 2 mg/ml; DMSO: 16 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 5 mg/ml
form	crystalline
color	off-white
Water Solubility	almost transparency
λmax	λ: 240 nm Amax: 0.04 λ: 250 nm Amax: 0.03 λ: 260 nm Amax: 0.02 λ: 500 nm Amax: 0.02
Merck	14,2847
BRN	3728288
Stability	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	541-22-0(CAS DataBase Reference)
FDA UNII	55C6RK944K
EPA Substance Registry System	Decamethonium dibromide (541-22-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P261-P301+P310-P305+P351+P338

Hazard Codes

Risk Statements

25-36/37/38

Safety Statements

26-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

BP5950000

3-10

HS Code

2923.90.0100

HazardClass

6.1(b)

PackingGroup

III

Toxicity

LD50 oral in mouse: 190mg/kg

NFPA 704

	0
2		0

DECAMETHONIUM BROMIDE price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D1260	Decamethonium bromide crystalline	541-22-0	5g	$129	2024-03-01	Buy
Sigma-Aldrich	D1260	Decamethonium bromide crystalline	541-22-0	10g	$239	2024-03-01	Buy
TCI Chemical	D1314	Decamethonium Bromide >98.0%(T)	541-22-0	5g	$66	2024-03-01	Buy
TCI Chemical	D1314	Decamethonium Bromide >98.0%(T)	541-22-0	25g	$198	2024-03-01	Buy
Cayman Chemical	24907	Decamethonium (bromide) ≥98%	541-22-0	1g	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
D1260	5g	$129	Buy
D1260	10g	$239	Buy
D1314	5g	$66	Buy
D1314	25g	$198	Buy
24907	1g	$32	Buy

DECAMETHONIUM BROMIDE Chemical Properties,Uses,Production

Description

Decamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC₅₀ value of 40 μM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC₅₀ values of 7.4, 405, 28, and 59 μM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC₅₀ = 52 μM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED₉₅ values of 35 and 70 μg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.

Chemical Properties

crystalline solid

Uses

antipsychotic

brand name

Syncurine (GlaxoSmithKline).

Biological Functions

Decamethonium was one of the first neuromuscular blocking agents to be synthesized. An SAR study on a series of bis-quaternary ammonium compounds with varying numbers of methylene groups separating the nitrogen atoms demonstrated that maximal neuromuscular blockade occurred with 10 to 12 unsubstituted methylene groups. Activity diminished as the number of carbons was either decreased or increased. The compound with six methylene groups, hexamethonium, is a nicotinic antagonist at autonomic ganglia (ganglionic blocking agent). All the compounds in this series that possessed neuromuscular blocking activity also caused depolarization of the postjunctional membrane.

General Description

Crystals derived from methanol and acetone.

Air & Water Reactions

Water soluble.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition DECAMETHONIUM BROMIDE emits very toxic fumes.

Fire Hazard

Flash point data for DECAMETHONIUM BROMIDE are not available. DECAMETHONIUM BROMIDE is probably combustible.

DECAMETHONIUM BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

DECAMETHONIUM BROMIDE Suppliers

Global( 111)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	3942	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22784	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49978	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58

Supplier	Advantage
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58

View Lastest Price from DECAMETHONIUM BROMIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Decamethonium bromide 541-22-0	US $45.00 / mg		99.79%	10g	TargetMol Chemicals Inc.
2024-11-19	Decamethonium bromide 541-22-0	US $45.00 / mg		99.79%	10g	TargetMol Chemicals Inc.
2021-07-08	DECAMETHONIUM BROMIDE USP/EP/BP 541-22-0	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited

Decamethonium bromide
541-22-0
US $45.00 / mg
99.79%
TargetMol Chemicals Inc.

Decamethonium bromide
541-22-0
US $45.00 / mg
99.79%
TargetMol Chemicals Inc.

DECAMETHONIUM BROMIDE USP/EP/BP
541-22-0
US $1.10 / g
99.9%
Dideu Industries Group Limited

DECAMETHONIUM BROMIDE Spectrum

DECAMETHONIUM BROMIDE(541-22-0)¹HNMR DECAMETHONIUM BROMIDE(541-22-0)¹³CNMR DECAMETHONIUM BROMIDE(541-22-0)IR1 DECAMETHONIUM BROMIDE(541-22-0)IR2 DECAMETHONIUM BROMIDE(541-22-0)Raman

541-22-0(DECAMETHONIUM BROMIDE)Related Search:

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1,10-Decanediaminium,N,N,N,N’,N’,N’-hexamethyl-,dibromide 10-decanediaminium,n,n,n,n’,n’,n’-hexamethyl-dibromide decacuran decamethoniumdibromide decamethylene-1,10-bistrimethylammoniumdibromide decamethylenebis(trimethyl-ammoniudibromide 1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2) dekamethoniumbromid DECANE-1,10-BIS(TRIMETHYLAMMONIUM BROMIDE) DECAMETHONIUM BROMIDE DECAMETHYLENEBIS[TRIMETHYL-AMMONIUM BROMIDE] syncurine DECAMETHONIUM BROMIDE, FOR ION PAIR CHRO MATOGRAPHY 1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, monobromide Ammonium, decamethylenebis[trimethyl-, dibromide Decamethonium bromide ,98% N1,N1,N1,N10,N10,N10-hexaMethyldecane-1,10-diaMiniuM broMide Decamethylene bis(trimethylammonium bromide), Decane-1,10-bis(trimethylammonium bromide) Decamethonium Bromide > DECAMETHONIUM BROMIDE USP/EP/BP Decamethonium (Bromide)(Reagent for Ion-Pair Chromatography,99%) nAChR,Decamethonium bromide,inhibit,Inhibitor,Decamethonium,Nicotinic acetylcholine receptors Decamethonium Bromide, ≥ 98.0% 541-22-0 C16H38N22Br CH33NBrCH210NBrCH33 C16H38Br2N2 C16H38N2Br2 Br2C16H38N2 Analytical Chromatography Product Catalog BioChemical Ammonium Salts Cell Biology Cell Signaling and Neuroscience Ion Channels Nicotinic Acetylcholine Receptor Modulators Phase Transfer Catalysts Synthetic Reagents Quaternary Ammonium Compounds Ammonium Bromides (Quaternary) HPLC Ligand-Gated Ion Channels Ion Pair Reagents - Anionic Ion Pair Reagents IMPROMEN Ammonium Bromides (Quaternary) Quaternary Ammonium Compounds