Chinese Japanese Germany Korea

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Structure
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide structure
CAS No.
15533-09-2
Chemical Name:
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
Synonyms
Compound C108;Compound C108 >=98% (HPLC);Compound C108,Compound C-108;2-Hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide;(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide;2-hydroxy-benzoicacid,2-[1-(2-hydroxyphenyl)ethylidene]hydrazide;Benzoic acid, 2-hydroxy-, 2-[1-(2-hydroxyphenyl)ethylidene]hydrazide
CBNumber:
CB64154983
Molecular Formula:
C15H14N2O3
Molecular Weight:
270.28
MDL Number:
MFCD00565556
MOL File:
15533-09-2.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
Request For Quotation

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Properties

Density 1.24±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMF:1.0(Max Conc. mg/mL);3.7(Max Conc. mM)
DMSO:1.0(Max Conc. mg/mL);3.7(Max Conc. mM)
form powder
pka 8.27±0.35(Predicted)
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2017 Compound C108 ≥98% (HPLC) 15533-09-2 5mg $105 2024-03-01 Buy
Sigma-Aldrich SML2017 Compound C108 ≥98% (HPLC) 15533-09-2 25mg $202.8 2024-03-01 Buy
Cayman Chemical 9002951 Compound C108 ≥98% 15533-09-2 500μg $73 2024-03-01 Buy
Cayman Chemical 9002951 Compound C108 ≥98% 15533-09-2 1mg $138 2024-03-01 Buy
Cayman Chemical 9002951 Compound C108 ≥98% 15533-09-2 5mg $575 2024-03-01 Buy
Product number Packaging Price Buy
SML2017 5mg $105 Buy
SML2017 25mg $202.8 Buy
9002951 500μg $73 Buy
9002951 1mg $138 Buy
9002951 5mg $575 Buy

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Chemical Properties,Uses,Production

Uses

2-Hydroxy-benzoic Acid [1-(2-Hydroxyphenyl)ethylidene]hydrazide is a GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) inhibitor. G3BP2 is involved with breast tumor initiation.

Biochem/physiol Actions

C108 is a small molecule that exhibits cancer-selective cytotoxicity (Viability = 100%/MCF-10A vs. 50%/BT-474, 67%/4T1, 70%/MDA-MB-231 & MDA-MB-453 post 48 h 1 μM C108 treatment) and synergizes with low dose paclitaxel in reducing ALDH-positive tumor-initiating cells (TIC poulation = 56.6%/control, 60.6%/0.1 μM paclitaxel alone, 47.4%/1 μM C108 alone, 7.3%/combined treatment for 24 h in BT474 breast cancer cultures) by targeting stress granule-associated protein G3BP2 (GAP SH3 domain-binding protein 2). Likewise, C108 pretreatment prior to xenografting greatly reduces BT-474 tumor-initiating frequency (from 1/175 to 1/1103 by limiting dilution xenograft assays) in mice in vivo. G3BP2 is reported to bind and stabilize SART3 mRNA, thereby indirectly regulating the core pluripotency transcription factors Oct-4 and Nanog critically involved in ESC self-renewal and breast tumor initiation.

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide synthesis

118-93-4
936-02-7
15533-09-2
Synthesis of (E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide from 2'-Hydroxyacetophenone and Salicylhydrazide

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 4600 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44807 58
Shanghai Universal Biotech Co.,Ltd 13774214275 zhouzz@univ-bio.com China 24990 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62075 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Sigma-Aldrich 80
Shanghai EFE Biological Technology Co., Ltd. 58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Shanghai Universal Biotech Co.,Ltd 58
Bide Pharmatech Ltd. 58

View Lastest Price from (E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Compound C108 pictures 2024-11-19 Compound C108
15533-09-2
 US $38.00-132.00 / mg 99.77% 10g TargetMol Chemicals Inc.
  • Compound C108 pictures
  • Compound C108
    15533-09-2
  • US $38.00-132.00 / mg
  • 99.77%
  • TargetMol Chemicals Inc.

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Spectrum

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide(15533-09-2)1HNMR
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Compound C108 Compound C108 >=98% (HPLC) Compound C108,Compound C-108 Benzoic acid, 2-hydroxy-, 2-[1-(2-hydroxyphenyl)ethylidene]hydrazide 2-hydroxy-benzoicacid,2-[1-(2-hydroxyphenyl)ethylidene]hydrazide 2-Hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide 15533-09-2