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2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE structure

CAS No.: 182004-65-5

Chemical Name:: 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE

Synonyms: IN1281;KB-R7943;KB-R7943 MESYLATE;KB-R7943 - CAS 182004-65-5 - Calbiochem;-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE;2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE;S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate;4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate;S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate >2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA, METHANE SULFONATE

CBNumber:: CB6422033

Molecular Formula:: C17H21N3O6S2

Molecular Weight:: 427.49

MDL Number:: MFCD00952138

MOL File:: 182004-65-5.mol

Last updated:2024-11-19 23:02:33

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2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Properties

Melting point	>214°C (dec.)
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in DMSO (up to 50 mg/ml).
form	White crystalline solid
color	Tan
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H400
Precautionary statements	P273-P391-P501
HS Code	2930.90.2900

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	N0966	S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate >98.0%(HPLC)	182004-65-5	10mg	$132	2024-03-01	Buy
TCI Chemical	N0966	S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate >98.0%(HPLC)	182004-65-5	50mg	$459	2024-03-01	Buy
Cayman Chemical	16352	KB-R7943 (mesylate) ≥98%	182004-65-5	5mg	$49	2024-03-01	Buy
Cayman Chemical	16352	KB-R7943 (mesylate) ≥98%	182004-65-5	10mg	$77	2024-03-01	Buy
Cayman Chemical	16352	KB-R7943 (mesylate) ≥98%	182004-65-5	50mg	$310	2024-03-01	Buy

Product number	Packaging	Price	Buy
N0966	10mg	$132	Buy
N0966	50mg	$459	Buy
16352	5mg	$49	Buy
16352	10mg	$77	Buy
16352	50mg	$310	Buy

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Chemical Properties,Uses,Production

Description

KB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50‘s = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) Ki = 5.5 μM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM) and block NMDA receptors (IC50 = 13.4 μM).4

Uses

KB-R7943 Mesylate is a selective inhibitor of the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.

General Description

A cell-permeable inhibitor of the influx/reverse mode of the Na⁺/Ca²⁺ exchanger (NCX) (IC₅₀ = 4.3 μM for NCX1, 4.7 μM for NCX2, and 1.4 μM for NCX3). Directly modulates Na⁺/Mg²⁺ exchange in a Ca²⁺-dependent manner. Reported ot offer neuronal and cardio-protection against ischemic injury. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC₅₀<10 μM).

Biological Activity

Potent, selective inhibitor of the reverse mode of the Na + /Ca 2+ exchanger (IC 50 = 0.7 mM). Does not affect Na + -dependent transport systems, Na + channels or ionotropic glutamate receptors.

Biochem/physiol Actions

Target IC50: 4.3 μM, 4.7 μM, and 1.4 μM for NCX1,NCX2, and NCX3, respectively

storage

Room temperature

References

1) Iwamoto et al. (1996), Novel Isothiourea Derivative Selectively Inhibits the Reverse Mode of Na+/Ca2+ Exchange in Cells Expressing NCX1; J. Biol .Chem., 271 22391 2) Hoyt et al. (1998) Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons; Mol. Pharmacol., 53 742 3) Santo-Domingo et al. (2007) The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter; Br. J. Pharmacol., 151 647 4) Brustovetsky et al. (2011) KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I; Br. J. Pharmacol,. 162 255

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Suppliers

Global( 106)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9245	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Hefei Hirisun Pharmatech Co., Ltd	58
Henan Aochuang Chemical Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58

View Lastest Price from 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	KB-R7943 mesylate 182004-65-5	US $50.00-131.00 / mg		≥95%	10g	TargetMol Chemicals Inc.
2022-09-08	KB-R7943 mesylate 182004-65-5	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2020-02-01	2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE 182004-65-5	US $1.00 / KG	1KG	99%	200kgs	Career Henan Chemical Co

KB-R7943 mesylate
182004-65-5
US $50.00-131.00 / mg
≥95%
TargetMol Chemicals Inc.

KB-R7943 mesylate
182004-65-5
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
182004-65-5
US $1.00 / KG
99%
Career Henan Chemical Co

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Spectrum

2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE(182004-65-5)¹HNMR

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Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester methanesulfonate Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester monomethanesulfonate KB-R7943 KB-R7943 MESYLATE 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE 2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA, METHANE SULFONATE S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate 4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate KB-R7943 - CAS 182004-65-5 - Calbiochem IN1281 KB R7943; KB-R 7943; KBR7943; 182004-65-5; KB-R7943 MESYLATE; 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE; IN1281; KB-R 7943 S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate > Carbamimidothioic Acid 4-[(4-Nitrobenzyl)oxy]phenethyl Ester Methanesulfonate -[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE 182004-65-5 C16H17N3O3SCH3SO3H C17H21N3O6S2 C16H17N3O3SCH4O3S CH4O3SC16H17N3O3S Signalling Ion transporter and other ion channel