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ZM 336372

ZM 336372 structure

CAS No.: 208260-29-1

Chemical Name:: ZM 336372

Synonyms: CS-44;ZM 336372;Zinc00581684;ZM 336372, >=98%;Probucol (DH-581);ZM 336372;ZM-336372;ZM 336372 USP/EP/BP;ZM 336372, 10 mM in DMSO;ZM 336372; ZM-336372;ZINC00581684;ZM 336372 - CAS 208260-29-1 - Calbiochem

CBNumber:: CB6428631

Molecular Formula:: C23H23N3O3

Molecular Weight:: 389.45

MDL Number:: MFCD02683971

MOL File:: 208260-29-1.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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ZM 336372 Properties

Boiling point	484.4±45.0 °C(Predicted)
Density	1.298
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: >5mg/mL (warmed)
pka	8.31±0.15(Predicted)
form	powder
color	white to beige
Sensitive	Light Sensitive
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
UNSPSC Code	12352117
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H317-H413

Precautionary statements

P261-P272-P273-P280-P302+P352-P333+P313

WGK Germany

HS Code

2924297099

NFPA 704

	0
2		0

ZM 336372 price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	J65730	ZM 336372	208260-29-1	1mg	$51.9	2021-12-16	Buy
Alfa Aesar	J65730	ZM 336372	208260-29-1	5mg	$230	2021-12-16	Buy
Cayman Chemical	10010367	ZM 336372 >98%	208260-29-1	1mg	$43	2024-03-01	Buy
Cayman Chemical	10010367	ZM 336372 >98%	208260-29-1	5mg	$85	2024-03-01	Buy
Sigma-Aldrich	692000	ZM 336372 - CAS 208260-29-1 - Calbiochem	208260-29-1	1mg	$230	2024-03-01	Buy

Product number	Packaging	Price	Buy
J65730	1mg	$51.9	Buy
J65730	5mg	$230	Buy
10010367	1mg	$43	Buy
10010367	5mg	$85	Buy
692000	1mg	$230	Buy

ZM 336372 Chemical Properties,Uses,Production

Description

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC₅₀ = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.

Uses

It is small molecule tyrosine kinase modulator. ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines.

Definition

ChEBI: 3-(dimethylamino)-N-[3-[[(4-hydroxyphenyl)-oxomethyl]amino]-4-methylphenyl]benzamide is a member of benzamides.

References

1) Hall-Jackson et al. (1999), Paradoxical activation of Raf by a novel Raf inhibitor; Chem. Biol., 6 559 2) Deming et al. (2010), ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines; J. Surg. Res., 161 28

ZM 336372 Preparation Products And Raw materials

Raw materials

Preparation Products

ZM 336372 Suppliers

Global( 148)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29879	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22787	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10986	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

View Lastest Price from ZM 336372 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	ZM 336372 208260-29-1	US $34.00-88.00 / mg		97.51%	10g	TargetMol Chemicals Inc.
	2019-09-05	N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE 208260-29-1	US $1.00 / ASSAYS	1ASSAYS	96%	10kg	Career Henan Chemical Co

ZM 336372
208260-29-1
US $34.00-88.00 / mg
97.51%
TargetMol Chemicals Inc.

N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE
208260-29-1
US $1.00 / ASSAYS
96%
Career Henan Chemical Co

ZM 336372 Spectrum

ZM 336372(208260-29-1)¹HNMR

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N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE ZM 336372 Zinc00581684 3-(DIMETHYLAMINO)-N-[3-[(4-HYDROXYBENZOYL)-AMINO]-4-METHYLPHENYL]BENZAMIDE 3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]- ZM 336372 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide ZM 336372, >=98% ZM 336372;ZM-336372 ZM 336372 - CAS 208260-29-1 - Calbiochem CS-44 ZM 336372; ZM-336372;ZINC00581684 ZM 336372 USP/EP/BP Probucol (DH-581) ZM 336372, 10 mM in DMSO 208260-29-1 08260-29-1 C23H23N3O3 Inhibitors MAPK A potent and specific inhibitor of the protein kinase c-Raf. Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals