Piroctone olamine
- CAS No.
- 68890-66-4
- Chemical Name:
- Piroctone olamine
- Synonyms
- OCTOPIROX;OCTO;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one;PIROCTONE OLEAMINE;LGB-PO;octopiroxolamine;PIROCTONE OLAMINE;Piorctone Olamine;PiroCLone olaMine;Pirotone Oleamine
- CBNumber:
- CB6433396
- Molecular Formula:
- C16H30N2O3
- Molecular Weight:
- 298.43
- MDL Number:
- MFCD01690792
- MOL File:
- 68890-66-4.mol
Melting point | 134.0 to 138.0 °C |
---|---|
Boiling point | 135-235℃[at 101 325 Pa] |
Density | 1.1[at 20℃] |
vapor pressure | 0-0Pa at 20-25℃ |
storage temp. | Inert atmosphere,2-8°C |
solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) |
pka | 5.9-7.4[at 20 ℃] |
form | Solid |
color | White to Off-White |
Water Solubility | 400-50000mg/L at 20-25℃ |
Merck | 14,7502 |
InChI | InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2 |
InChIKey | BTSZTGGZJQFALU-UHFFFAOYSA-N |
SMILES | C(N)CO.C(C1=CC(C)=CC(=O)N1O)C(C)CC(C)(C)C |
LogP | 1.05-3.86 at 20-25℃ |
CAS DataBase Reference | 68890-66-4(CAS DataBase Reference) |
EWG's Food Scores | 1-2 |
FDA UNII | A4V5C6R9FB |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05 |
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Signal word | Danger | |||||||||
Hazard statements | H315-H318-H412 | |||||||||
Precautionary statements | P273-P280-P302+P352-P305+P351+P338+P310 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | UU7786150 | |||||||||
HS Code | 2933399090 | |||||||||
NFPA 704 |
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Piroctone olamine price More Price(24)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 51872 | Piroctone olamine analytical standard | 68890-66-4 | 100mg | $142 | 2024-03-01 | Buy |
Sigma-Aldrich | 1544406 | Piroctone olamine United States Pharmacopeia (USP) Reference Standard | 68890-66-4 | 200mg | $436 | 2024-03-01 | Buy |
TCI Chemical | P2178 | Piroctone Olamine >97.0%(HPLC)(T) | 68890-66-4 | 1g | $141 | 2024-03-01 | Buy |
TCI Chemical | P2178 | Piroctone Olamine >97.0%(HPLC)(T) | 68890-66-4 | 5g | $471 | 2024-03-01 | Buy |
Sigma-Aldrich | PHR2187 | Piroctone Olamine Pharmaceutical Secondary Standard; Certified Reference Material | 68890-66-4 | 500mg | $689 | 2024-03-01 | Buy |
Piroctone olamine Chemical Properties,Uses,Production
Description
Piroctone olamine (INN; also known as piroctone ethanolamine; brand name Octopirox) is a compound sometimes used in the treatment of fungal infections.Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Appearance
White or slightly yellow crystalline powder.
Solubility
Freely soluble in 10% ethanol in water; soluble in solution containing surfactants in water or in 1%-10% ethanol; slightly soluble in water and in oil. The solubility in water varies by pH value, and is a litter larger in neutral or weak basic solution than in acid solution.
Toxicity
Acute toxicity : Acute oral LD50 –rat 8100mg/kg, practically nontoxic.
Subchronic toxicity : NOEL: 100mg//kg/d (rat, orally, 3 months).
Chronic toxicity and carcinogencity : Negative.
Mutagenicity : Negative.
Irritation to skin and eye : Very low.
Uses
Piroctone Olamine is an anti-dandruff agent used in shampoo formulations.
Uses
Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.
Definition
ChEBI: An organoammonium salt that is the ethanolamine salt of piroctone.
brand name
Octopirox (Hoechst AG, Germany).
Mechanism of action
Piroctone olamine, also known as Octopirox, is an antifungal and antibacterial agent commonly used in cosmetic and personal care products, such as shampoos, conditioners, and lotions. It works by inhibiting the growth of various microorganisms, including yeasts and fungi, by disrupting their cell membranes and interfering with their metabolism. Specifically, piroctone olamine targets the enzymes responsible for synthesizing the cell membrane of microorganisms, inhibiting their growth and causing their eventual death. It also has anti-inflammatory properties that help to reduce redness and itching on the scalp and skin.
Side effects
It should be kept in mind that shampoos with Piroctone Olamine should not be used more than twice a week, unlike other daily-use shampoos that don't have this ingredient. One of the biggest side effects of Piroctone Olamine is that it can cause irritation and itchiness on the head.
Piroctone olamine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 11506 | 58 |
EAST STAR BIOTECH (SUZHOU) CO., LTD. | +8617706846989 | marketing@eaststarbio.com | China | 48 | 58 |
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
Aceschem Inc. | +1-817863-6948 +1-(817)863-6948 | sales@aceschem.com | United States | 19639 | 58 |
BLiT (Hefei)Chemical Co.,Ltd | +86-551-62622640 | sales@blitchem.com | China | 293 | 58 |
Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 8661 | 58 |
Beri Pharma Co., Ltd. | +8613417710166 | sales@zhberi.com | China | 210 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +undefined18532138899 | L18532138899@163.com | China | 931 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | daisy@crovellbio.com | China | 5831 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
View Lastest Price from Piroctone olamine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-14 | Piroctone olamine
68890-66-4
|
US $0.00 / kg | 1kg | 99% | 50000KG/month | Hebei Mojin Biotechnology Co.,Ltd | ||
2024-08-14 | Piroctone olamine
68890-66-4
|
US $1.00 / KG | 1KG | ≥99% | 1000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-08-14 | Piroctone olamine
68890-66-4
|
US $0.00 / KG | 1KG | 99% | 1000 TONS | BLiT (Hefei)Chemical Co.,Ltd |
- Piroctone olamine
68890-66-4
- US $0.00 / kg
- 99%
- Hebei Mojin Biotechnology Co.,Ltd
- Piroctone olamine
68890-66-4
- US $1.00 / KG
- ≥99%
- WUHAN FORTUNA CHEMICAL CO., LTD
- Piroctone olamine
68890-66-4
- US $0.00 / KG
- 99%
- BLiT (Hefei)Chemical Co.,Ltd