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SULFISOMIDINE

SULFISOMIDINE Structure
SULFISOMIDINE structure
CAS No.
515-64-0
Chemical Name:
SULFISOMIDINE
Synonyms
Sulfaisodimidine;SULFISOMIDIN;Domian;erycon;Elcosin;Elkosil;Elkosin;Mefenal;Elcosine;Elkosine
CBNumber:
CB6455785
Molecular Formula:
C12H14N4O2S
Molecular Weight:
278.33
MDL Number:
MFCD00010567
MOL File:
515-64-0.mol
MSDS File:
SDS
Last updated:2024-11-20 11:41:24
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SULFISOMIDINE Properties

Melting point 245°C
Boiling point 294°C (rough estimate)
Density 1.2997 (rough estimate)
refractive index 1.6440 (estimate)
storage temp. 0-6°C
solubility Acetonitrile (Slightly), DMSO (Slightly)
pka pKa 7.25 (Uncertain)
form Solid
color White to Off-White
Water Solubility 1.382g/L(25 ºC)
Merck 8951
BRN 261305
FDA UNII W03L3ODK6E
ATC code J01EB01

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
RIDADR  3249
WGK Germany  2
RTECS  WO9270000
HazardClass  6.1(b)
PackingGroup  III

SULFISOMIDINE price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46908 Sulfisomidin VETRANAL?, analytical standard 515-64-0 250mg $53.6 2022-05-15 Buy
TRC S699378 Sulfisomidine 515-64-0 25mg $45 2021-12-16 Buy
Biosynth Carbosynth FA131378 4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide 515-64-0 500mg $50 2021-12-16 Buy
Matrix Scientific 136051 4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide 95%+ 515-64-0 5g $323 2021-12-16 Buy
American Custom Chemicals Corporation API0007837 SULFISOMIDINE 95.00% 515-64-0 10MG $400.3 2021-12-16 Buy
Product number Packaging Price Buy
46908 250mg $53.6 Buy
S699378 25mg $45 Buy
FA131378 500mg $50 Buy
136051 5g $323 Buy
API0007837 10MG $400.3 Buy

SULFISOMIDINE Chemical Properties,Uses,Production

Originator

Elkosin,Ciba,US,1951

Uses

Sulfisomidine is a sulfanilamide antibacterial agent.

Definition

ChEBI: A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.

Manufacturing Process

This starting material can be prepared as follows. 123 parts of finely powdered 6-amino-2,4-dimethylpyrimidine are suspended in 250 parts of dry pyridine and 222 parts of p-nitrobenzenesulfonyl chloride added at 50°C to 55°C. The whole is then warmed for 2 hours to 55°C. Water is added to the crystalline aggregate obtained, the precipitated bis-N-(pnitrobenzenesulfonyl)- 6-amino-2,4-dimethylpyrimidine filtered off by suction and washed with water. It is purified by recrystallizing from methyl ethyl ketone. On slowly heating it decomposes; on rapidly heating it melts at about 210°C to 215°C with decomposition.
49.3 parts of bis-N-(p-nitrobenzenesulfonyl)-6-amino-2,4-dimethylpyrimidine are heated to boiling for one hour with 12.3 parts of 6-amino-2,4- dimethylpyrimidine in 50 parts of dry pyridine. After cooling, the 6-(pnitrobenzenesulfonamido)- 2,4-dimethylpyrimidine formed is precipitated with water and filtered off by suction. It is purified by dissolving in dilute caustic soda and precipitating with acid. On recrystallization from dilute alcohol it melts (with decomposition) at 188°C to 189°C.
On reaction, for example, with iron and hydrochloric acid, 6-(paminobenzenesulfonamido)- 2,4-dimethylpyrimidine, melting point 236°C is obtained.

brand name

Isosulf;Oestro-gynedron;Poly-gynedron;Sulfamethine;Tricho-gynedron.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Sulfisomide, a sulfonamide anti-infective agent, was introduced several decades ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfisomide is still used topically in some countries for vaginal infection.

Pharmaceutical Applications

6-Sulfanilamido-2,4-dimethylpyrimidine (syn: sulphasomidine). A highly soluble sulfonamide with a plasma half-life of 6–8 h. Protein binding is about 90%. Activity is similar to that of sulfadiazine. It is less extensively metabolized than most other sulfonamides and is largely excreted unchanged in the urine.

SULFISOMIDINE synthesis

121-60-8
515-64-0
Synthesis of SULFISOMIDINE from N-Acetylsulfanilyl chloride

SULFISOMIDINE Preparation Products And Raw materials

Raw materials

Hydrochloric acid 4-Nitrobenzenesulfonyl chloride

Preparation Products

SULFISOMIDINE Suppliers

Global( 142)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29884 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34553 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14394 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Shaanxi Didu New Materials Co. Ltd 		+86-89586680 +86-13289823923 1026@dideu.com China 8670 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18154 58
Supplier Advantage
career henan chemical co 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Win-Win chemical CO., Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Shaanxi Didu New Materials Co. Ltd 		58
LEAP CHEM CO., LTD. 		58
Hebei Weibang Biotechnology Co., Ltd 		58

View Lastest Price from SULFISOMIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sulfisomidin pictures 2024-11-19 Sulfisomidin
515-64-0
 US $31.00 / mg 99.62% 10g TargetMol Chemicals Inc.
SULFISOMIDINE pictures 2019-07-06 SULFISOMIDINE
515-64-0
 US $1.00 / KG 1G 98% 100KG Career Henan Chemical Co
  • Sulfisomidin pictures
  • Sulfisomidin
    515-64-0
  • US $31.00 / mg
  • 99.62%
  • TargetMol Chemicals Inc.

SULFISOMIDINE Spectrum

SULFISOMIDINE(515-64-0)MSSULFISOMIDINE(515-64-0)1HNMRSULFISOMIDINE(515-64-0)13CNMRSULFISOMIDINE(515-64-0)IR1SULFISOMIDINE(515-64-0)IR2

515-64-0(SULFISOMIDINE)Related Search:

SULFISOMIDINE Sulfaclomid Sulfanilamide 4-AMINO-2,6-DIMETHYLPYRIMIDINE SULFISOMIDINE, SODIUM
AURORA 8501 AURORA 10892 AURORA 7814 AURORA 22997 N-(4-(((2,6-DIMETHYLPYRIMIDIN-4-YL)AMINO)SULFONYL)PHENYL)-2-THIENYLFORMAMIDE
2-ACETYL-3-((4-(((2,6-DIMETHYLPYRIMIDIN-4-YL)AMINO)SULFONYL)PHENYL)AMINO)-N-PHENYLPROP-2-ENAMIDE 2-(((4-(((2,6-DIMETHYLPYRIMIDIN-4-YL)AMINO)SULFONYL)PHENYL)AMINO)METHYLENE)INDANE-1,3-DIONE AURORA 9455 AURORA 22995 AURORA 11359
AURORA 7318 AURORA 1185 AURORA 10804

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(p-aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin (p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidine 2,4-Dimethyl-6-sulfanilamidopyrimidine 2,6-Dimethyl-4-sulfanilamidopyrimidine 4-amino-n-(2,6-dimethyl-4-pyrimidinyl)-benzenesulfonamid 4-Sulfa-2,6-dimethylpyrimidine 4-Sulfanilamido-2,6-dimethylpyrimidine 6-(4-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine 6-(p-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine 6-(p-Aminobenzenesulfonyl)amino-2,4-dimethylpyrimidine 6-(p-aminophenylsulfonamido)-2,4-dimethylpyrimidine 6-[(p-aminobenzenesulfonyl)amino]-2,4-dimethylpyrimidine 6-Sulfanilamido-2,4-dimethylpyrimidine Aristamid Aristamide Aristogyn Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)- benzenesulfonamide,4-amino-N-(2,6-dimethyl-4-pyrimidinyl)- Domian Elcosin N1-(2,6-DIMETHYLPYRIMIDIN-4-YL)SULFANILAMIDE SULFISOMIDINE Elcosine Elkosil Elkosin Elkosine erycon Mefenal n(sup1)-(2,6-dimethyl-4-pyrimidinyl)-sulfanilamid n(sup1)-(2,6-dimethyl-4-pyrimidinyl)sulfanilamide N1-(2,6-Dimethyl-4-pyrimidinyl)sulfanilamide N1-(2,6-dimethyl-4-pyrimidinyl)sulfanilamide Sulfadimetine Sulfaisodimerazine Sulfamethin 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide, N1-(2,6-Dimethylpyrimidin-4-yl)sulfanilamide 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide 4-azanyl-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide SULFISOMIDIN VETRANAL Sulfisomidine solution,100ppm (p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin [German] 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide (9CI) 6-(p-Aminobenzenesulfo Sulfisomidine (JAN) Sulfisomidine (TN) Sulfanilamide, N1-(2,6-dimethyl-4-pyrimidinyl)- sulfanilamide,N1-(2,6-dimethyl-4-pyrimidinyl)- Sulfasomidine Sulphasomidine AKOS BBS-00004571 4-AMINO-N-(2,6-DIMETHYL-4-PYRIMIDINYL)BENZENESULFONAMIDE N1-(2,6-dimethylpyrimidin-4-yl)sulphanilamide SULPHISOMIDINE SULFISOMIDINE STANDARD Sulfisomidine > Sulfisomidine Solution in Methanol, 1000μg/mL SULFISOMIDINE USP/EP/BP SULFISOMIDIN