(+)-D-threo-PDMP (hydrochloride)
- CAS No.
- 139889-62-6
- Chemical Name:
- (+)-D-threo-PDMP (hydrochloride)
- Synonyms
- (+)-D-threo-PDMP (hydrochloride);(+) D threo PDMP (hydrochloride),(+)DthreoPDMP (hydrochloride)
- CBNumber:
- CB64665650
- Molecular Formula:
- C23H39ClN2O3
- Molecular Weight:
- 427.03
- MDL Number:
- MOL File:
- 139889-62-6.mol
(+)-D-threo-PDMP (hydrochloride) price More Price(1)
(+)-D-threo-PDMP (hydrochloride) Chemical Properties,Uses,Production
Description
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP .1 (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase.2,3 It inhibits glucosylceramide synthase by 50% when used at a concentration of 5 μM in an enzyme assay.3 (+)-D-threo-PDMP is the active component of racemic DL-threo-PDMP . In vitro, (+)-D-threo-PDMP inhibits the synthesis of glucosylceramide synthase and lactosylceramide in B16 melanoma cells when used at a concentration of 25 μM and inhibits cell binding to laminin and collagen when used at concentrations of 10 and 25 μM.4 It also inhibits β-1,4-galactosyltransferase 6 (B4GALT6) and prevents lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.5 (+)-D-threo-PDMP inhibits ganglioside biosynthesis, reduces long-term potentiation (LTP) in mouse hippocampal CA1 neurons, and impairs learning in the four-pellet taking test in mice.6
References
1. Vunnam, R.R., and Radin, N.S. Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain Chem. Phys. Lipids 26(3),265-278(1980).
2. Abe, A., Inokuchi, J.-i., Jimbo, M., et al. Improved inhibitors of glucosylceramide synthase J. Biochem. 111(2),191-196(1992).
3. Inokuchi, J.i., and Radin, N.S. Preparation of the active isomer of 1-
4. Inokuchi, J.-I., Momosaki, K., Shimeno, H., et al. Effects of D-
5. Mayo, L., Trauger, S.A., Blain, M., et al. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation Nat. Med. 20(10),1147-1156(2014).
6. Fujiwara, H., Ikarashi, K., Yamazaki, Y., et al. Impairment of hippocampal long-
(+)-D-threo-PDMP (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-D-threo-PDMP (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai meikai technology co., ltd | 021-18721550-091 18721550091 | yangdong@pharma.com | China | 4123 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| Hubei Aiputi Bioengineering Co., Ltd. | 17762444226 | d17762444226@163.com | China | 2402 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 15102117276 19921389125 | tech@zzbioco.com | China | 12064 | 58 |