Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>CAY10706

CAY10706

CAY10706 Structure
CAY10706 structure
CAS No.
1881270-27-4
Chemical Name:
CAY10706
Synonyms
CAY10706;1,4-Pentadien-3-one, 1-(4-hydroxy-3-methoxyphenyl)-5-(3,5,6-trimethyl-2-pyrazinyl)-, (1E,4E)-
CBNumber:
CB64666354
Molecular Formula:
C19H20N2O3
Molecular Weight:
324.37
MDL Number:
MOL File:
1881270-27-4.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

CAY10706 Properties

Boiling point 496.8±45.0 °C(Predicted)
Density 1.198±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 1 mg/ml
form A crystalline solid
pka 9?+-.0.31(Predicted)

CAY10706 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19318 CAY10706 ≥95% 1881270-27-4 500μg $125 2021-12-16 Buy
Cayman Chemical 19318 CAY10706 ≥95% 1881270-27-4 1mg $225 2021-12-16 Buy
Cayman Chemical 19318 CAY10706 ≥95% 1881270-27-4 5mg $788 2021-12-16 Buy
Product number Packaging Price Buy
19318 500μg $125 Buy
19318 1mg $225 Buy
19318 5mg $788 Buy

CAY10706 Chemical Properties,Uses,Production

Description

CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells.1 It has been shown to inhibit the proliferation of drug-sensitive (A549 (IC50 = 2.19 μM), SPC-A-1 (IC50 = 3.12 μM), LTEP-G-2 (IC50 = 2.88 μM)) and drug-resistant (A549/DDP (IC50 = 0.6 μM)) lung cancer cells but demonstrates little effect on non-tumor lung epithelial-like cells (HBE (IC50 = 21.34 μM)).1 CAY10706 can suppress the thioredoxin reductase system and inhibit the NF-κB, Akt, and ERK signaling.1

References

1. Ai, Y., Zhu, B., Ren, C., et al. Discovery of new monocarbonyl ligustrazine-curcumin hybrids for intervention of drug-sensitive and drug-resistant lung cancer J. Med. Chem. 59(5),1747-1760(2016).

CAY10706 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10706 Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Nafu Biotechnology Co., Ltd. 021-58952328 13125124762 sale@chemhui.com China 491 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7982 58
Supplier Advantage
Shanghai Nafu Biotechnology Co., Ltd. 55
Shanghai Hongye Biotechnology Co. Ltd 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
CAY10706 1,4-Pentadien-3-one, 1-(4-hydroxy-3-methoxyphenyl)-5-(3,5,6-trimethyl-2-pyrazinyl)-, (1E,4E)- 1881270-27-4