AMG-333
- CAS No.
- 1416799-28-4
- Chemical Name:
- AMG-333
- Synonyms
- AMG-333;AMG333;AMG 333;AMG 333, 10 mM in DMSO;Inhibitor,AMG333,TRP Channel,inhibit,Transient receptor potential channels,AMG 333;(S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic acid;3-Pyridinecarboxylic acid, 6-[[[(S)-(3-fluoro-2-pyridinyl)[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]-
- CBNumber:
- CB64667528
- Molecular Formula:
- C20H12F5N3O4
- Molecular Weight:
- 453.32
- MDL Number:
- MFCD31813692
- MOL File:
- 1416799-28-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
AMG-333 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 6874 | AMG333 ≥98%(HPLC) | 1416799-28-4 | 50 | $715 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573119 | AMG-333 >98% | 1416799-28-4 | 100mg | $1208.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573119 | AMG-333 >98% | 1416799-28-4 | 250mg | $2097.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573119 | AMG-333 >98% | 1416799-28-4 | 1g | $4173.5 | 2021-12-16 | Buy |
| ChemScene | CS-0062825 | AMG333 99.76% | 1416799-28-4 | 5mg | $100 | 2021-12-16 | Buy |
AMG-333 Chemical Properties,Uses,Production
Uses
AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM.
in vivo
AMG 333 (0.6-3 mg/kg, p.o., single dose) dose-dependently inhibits wet-dog shake behavior in the Icilin (HY-11062)-induced wet-dog shake Sprague?Dawley rat model, demonstrating that AMG 333 effectively blocks the TRPM8 target[1]. AMG 333 (1-3 mg/kg, p.o., single dose) dose-dependently blocks blood pressure elevation in the cold stimulation-induced blood pressure elevation Sprague?Dawley rat model, indicating that AMG 333 effectively acts on the TRPM8 target[1].
| Animal Model: | Icilin (HY-11062)-induced wet-dog shake (WDS) behavior in Sprague?Dawley rat model[1] |
| Dosage: | 0.6, 1, 3 mg/kg |
| Administration: | Oral gavage (p.o.), single dose |
| Result: | Demonstrated significant dose-dependent inhibition; 3 mg/kg fully inhibited WDS. |
| Animal Model: | Cold stimulation-induced blood pressure elevation Sprague?Dawley rat model[1] |
| Dosage: | 1, 3 mg/kg |
| Administration: | Oral gavage (p.o.), single dose |
| Result: | Showed significant inhibition of cold-induced blood pressure elevation at 1 mg/kg and 3 mg/kg; 3 mg/kg fully blocked cold-pressor response. |
storage
Store at -20°C
References
[1] Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201. DOI:10.1021/acs.jmedchem.8b00518
AMG-333 Preparation Products And Raw materials
Raw materials
Preparation Products
AMG-333 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
