4,6-Dichloropyrimidine
- CAS No.
- 1193-21-1
- Chemical Name:
- 4,6-Dichloropyrimidine
- Synonyms
- NSC 37530;4,6-DichL;DichloropyriMidine;IFLAB-BB F2124-0077;4,6-Dichloropyrimidi;4,6-Dichloropyridine;4,6-Dichlorpyrimidin;4,6-Dichoropyrimidine;4,6-DICHLOROPYRIMIDINE;4,6-Dichloro-1,3-diazine
- CBNumber:
- CB6473590
- Molecular Formula:
- C4H2Cl2N2
- Molecular Weight:
- 148.98
- MDL Number:
- MFCD00006109
- MOL File:
- 1193-21-1.mol
- MSDS File:
- SDS
Melting point | 65-67 °C (lit.) |
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Boiling point | 176 °C (lit.) |
Density | 1.6445 (rough estimate) |
vapor pressure | 30-390Pa at 20-50℃ |
refractive index | 1.6300 (estimate) |
Flash point | 176°C |
storage temp. | Inert atmosphere,2-8°C |
solubility | 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow |
pka | -4.20±0.17(Predicted) |
form | Crystals |
color | Yellow-green |
BRN | 111195 |
InChIKey | XJPZKYIHCLDXST-UHFFFAOYSA-N |
LogP | 1.45 at 25℃ and pH7.2 |
Surface tension | 65.72mN/m at 1g/L and 20℃ |
CAS DataBase Reference | 1193-21-1(CAS DataBase Reference) |
FDA UNII | TTE9SA8H44 |
NIST Chemistry Reference | Pyrimidine, 4,6-dichloro-(1193-21-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS05 |
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Signal word | Danger | |||||||||
Hazard statements | H314 | |||||||||
Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
Hazard Codes | C | |||||||||
Risk Statements | 34-20/21/22-36/37 | |||||||||
Safety Statements | 26-36/37/39-45-27 | |||||||||
RIDADR | UN 3263 8/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
F | 19 | |||||||||
Hazard Note | Corrosive | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | II | |||||||||
HS Code | 29335990 | |||||||||
NFPA 704 |
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4,6-Dichloropyrimidine price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 145378 | 4,6-Dichloropyrimidine 97% | 1193-21-1 | 10g | $91.3 | 2024-03-01 | Buy |
Sigma-Aldrich | 145378 | 4,6-Dichloropyrimidine 97% | 1193-21-1 | 50g | $126.8 | 2024-03-01 | Buy |
TCI Chemical | D2488 | 4,6-Dichloropyrimidine >98.0%(GC) | 1193-21-1 | 5g | $16 | 2024-03-01 | Buy |
TCI Chemical | D2488 | 4,6-Dichloropyrimidine >98.0%(GC) | 1193-21-1 | 25g | $44 | 2024-03-01 | Buy |
Alfa Aesar | L13212 | 4,6-Dichloropyrimidine, 98% | 1193-21-1 | 25g | $133.65 | 2024-03-01 | Buy |
4,6-Dichloropyrimidine Chemical Properties,Uses,Production
Uses
4,6-Dichloropyrimidine (cas# 1193-21-1) is a compound useful in organic synthesis.
Chemical Properties
Yellow Solid
Uses
4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.
General Description
Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.
Synthesis
The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.
4,6-Dichloropyrimidine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhan Aoliqisi New Material Technology Co., Ltd. | +86-13545906766; +8613545906766 | sales@whaop.com | China | 265 | 58 |
Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5905 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
View Lastest Price from 4,6-Dichloropyrimidine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-22 | 4,6-Dichloropyrimidine
1193-21-1
|
US $0.00 / Kg/Drum | 1KG | 99%min | 1000KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-20 | 4,6-Dichloropyrimidine
1193-21-1
|
US $9.00 / KG | 1KG | 99.9 | 1 ton | Hebei Guanlang Biotechnology Co,.LTD | |
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2023-11-21 | 4,6-Dichloropyrimidine
1193-21-1
|
US $30.00 / g | 1000g | 99% | 20ton/month | Wuhan Aoliqisi New Material Technology Co., Ltd. |
-
- 4,6-Dichloropyrimidine
1193-21-1
- US $0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4,6-Dichloropyrimidine
1193-21-1
- US $9.00 / KG
- 99.9
- Hebei Guanlang Biotechnology Co,.LTD
-
- 4,6-Dichloropyrimidine
1193-21-1
- US $30.00 / g
- 99%
- Wuhan Aoliqisi New Material Technology Co., Ltd.
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