BRD2 Inhibitor II, BIC1 - Calbiochem
- CAS No.
- Chemical Name:
- BRD2 Inhibitor II, BIC1 - Calbiochem
- Synonyms
- BRD2 Inhibitor II, BIC1 - Calbiochem
- CBNumber:
- CB64816928
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
BRD2 Inhibitor II, BIC1 - Calbiochem price More Price(1)
BRD2 Inhibitor II, BIC1 - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable benzimidazolyl-benzimidazolothione that targets the BD1 domain of the BET family member BRD2 (Kd = 28 μM), making it inaccessible for acetylated H4K12 (histone H4 Lys12) binding. Shown to effectively inhibit TSA- (Cat. No. 647925; 1 h 1 μM) induced BRD2 BD1-H4K12 association in COS7 cells (100% inhibition by 60 μM BIC1) and greatly suppress active Ras-induced SV40 promoter transcription activity in HeLa cells (70% inhibition by 5 μM BIC1), while being much less effective against BRDT BD1 binding to acetylated H4K5/K8.
BRD2 Inhibitor II, BIC1 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
BRD2 Inhibitor II, BIC1 - Calbiochem Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |
BRD2 Inhibitor II, BIC1 - Calbiochem