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CH5447240 (CH-5447240)

CH5447240 (CH-5447240) structure

CAS No.: 1253919-92-4

Chemical Name:: CH5447240 (CH-5447240)

Synonyms: CH5447240 (CH-5447240);Urea, N-[3,5-dimethyl-4-[2-[[2-(trans-4-methylcyclohexyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-N-methyl-

CBNumber:: CB64844640

Molecular Formula:: C26H39N5O4S

Molecular Weight:: 517.68

MDL Number:: MFCD32695335

MOL File:: 1253919-92-4.mol

Last updated:2023-03-31 09:12:58

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CH5447240 (CH-5447240) Properties

Boiling point	701.7±70.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
pka	14.43±0.50(Predicted)

CH5447240 (CH-5447240) Chemical Properties,Uses,Production

Description

CH5447240 is a potent Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist for Treatment of Hypoparathyroidism. CH5447240 exhibited a potent in vitro hPTHR1 agonist effect with EC20 of 3.0 nM and EC50 of 12 nM and showed excellent physicochemical properties, such as high solubility in fasted state simulated intestinal fluid and good metabolic stability in human liver microsomes. mportantly, CH5447240 showed 55% oral bioavailability, and a significantly elevated serum calcium level in hypocalcemic model rats.

CH5447240 (CH-5447240) Preparation Products And Raw materials

Raw materials

Preparation Products

CH5447240 (CH-5447240) Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
DC Chemicals	58
TargetMol Chemicals Inc.	58

CH5447240 (CH-5447240) Urea, N-[3,5-dimethyl-4-[2-[[2-(trans-4-methylcyclohexyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-N-methyl- 1253919-92-4