4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride
![4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride Structure](CAS/20200401/GIF/1049740-32-0.gif)
- CAS No.
- 1049740-32-0
- Chemical Name:
- 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride
- Synonyms
- 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride;4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride
- CBNumber:
- CB64902764
- Molecular Formula:
- C22H28ClN3O
- Molecular Weight:
- 385.94
- MDL Number:
- MFCD08705336
- MOL File:
- 1049740-32-0.mol
4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride price
4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride Chemical Properties,Uses,Production
Biological Activity
a-331440 is described here instead of a-331440 dihydrochloride. a-331440 is an antagonist of non-imidazole histamine h3 receptor with an ic50 value of 22.7 nm for human cortex histamine h3 [1].histamine, as a neurotransmitter, is important in homeostasis and physiology. in the cns, histamine released has the potential to interact with h1, h2, h3 and possibly h4 receptors. all the receptors are g-protein coupled receptors [2].in hek 293 cells stably transfected with rat or human histamine h3 receptors, a-331440 was tested for its ability to antagonize increasing calcium mobilization in response to (r)-α-methylhistamine and showed pkb ± s.e.m. values of 7.38 ± 0.10 and 7.37 ± 0.29 for rat histamine h3 and human histamine h3, respectively [1].in mice, treatment with a-331440 at a dose of 100 mg/kg resulted in piloerection and hypoactivity in the first 2 h, but diminished thereafter. in naive male cd-1 mice, administration with comparable doses of a-331440 i.p. also produced similar data. by day 28, mice treated with a-331440 at the intermediate dose weighed 35.7 ± 0.93 g with an average weight loss of 5.3 ± 0.99 g. the high dose of a-331440 (15 mg/kg, p.o., b.i.d.) produced a marked and sustained weight loss [1].
References
[1]. hancock aa, bennani yl, bush en, et al. antiobesity effects of a-331440, a novel non-imidazole histamine h3 receptor antagonist. european journal of pharmacology, 2004, 487(1): 183-197.
[2]. hancock aa, diehl ms, faghih r, et al. in vitro optimization of structure activity relationships of analogues of a-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine h3 receptor antagonists. basic & clinical pharmacology & toxicology, 2004, 95(3): 144-152.
4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48467 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |