5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
- CAS No.
- 148892-91-5
- Chemical Name:
- 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
- Synonyms
- UQABYHGXWYXDTK-QXQKWMGSSA-N;Guanosine 5′-[β,γ-imido]triphosphate;5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM;Guanylyl Imidodiphosphate (trisodium);5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM;Guanylyl Imidodiphosphate Trisodium Salt;β:γ-imidoguanosine 5'-triphosphate trisodium salt;GUANOSINE-5-[(B GAMMA)-IMIDO]TRIPHOSPHATE SODIU...;guanosine 5'-[β,γ-imido]triphosphate trisodium salt;5′-Guanylyl-imidodiphosphate trisodium salt hydrate
- CBNumber:
- CB6497387
- Molecular Formula:
- C10H18N6NaO13P3
- Molecular Weight:
- 546.19
- MDL Number:
- MFCD00084770
- MOL File:
- 148892-91-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| F | 10-21 |
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G0635 | Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate ≥85% (HPLC), powder | 148892-91-5 | 5mg | $178 | 2024-03-01 | Buy |
| Sigma-Aldrich | G0635 | Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate ≥85% (HPLC), powder | 148892-91-5 | 25mg | $624 | 2024-03-01 | Buy |
| Cayman Chemical | 16880 | Guanylyl Imidodiphosphate ≥95% | 148892-91-5 | 1mg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 16880 | Guanylyl Imidodiphosphate ≥95% | 148892-91-5 | 5mg | $105 | 2021-12-16 | Buy |
| Sigma-Aldrich | G0635 | Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate ≥85% (HPLC), powder | 148892-91-5 | 100mg | $2000 | 2024-03-01 | Buy |
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Chemical Properties,Uses,Production
Uses
Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex.
Uses
Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.
General Description
Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Biochem/physiol Actions
Guanosine 5′-[?,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9900 | 58 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| BOC Sciences | 16314854226 | inquiry@bocsci.com | United States | 9713 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| JiangSu Star Science Co.,Ltd | 400-605-7200 17312445705 | sales022@b2star.com | China | 3764 | 58 |