GlcNAcstatin
- CAS No.
- 922163-64-2
- Chemical Name:
- GlcNAcstatin
- Synonyms
- GlcNAcstatin;Propanamide, 2-methyl-N-[(5R,6R,7R,8S)-5,6,7,8-tetrahydro-6,7-dihydroxy-5-(hydroxymethyl)-2-(2-phenylethyl)imidazo[1,2-a]pyridin-8-yl]-
- CBNumber:
- CB65707175
- Molecular Formula:
- C20H27N3O4
- Molecular Weight:
- 373.45
- MDL Number:
- MFCD26142655
- MOL File:
- 922163-64-2.mol
GlcNAcstatin Chemical Properties,Uses,Production
Description
GlcNAcstatin is a highly potent and competitive inhibitor of O-GlcNAcase (OGA) with Ki value of 4.4 nM for human OGA [1].
GlcNAcstatin is a synthetic GlcNAc-configured nagstatin derivative with a larger isobutanamido group on N8 and a phenethyl group on C2. It inhibited bacterial OGA with Ki value of 4.6 pM. For human OGA, GlcNAcstatin also showed a potent inhibition with Ki value of 4.4 nM. Besides that, GlcNAcstatin exerted inhibitory activity against human lysosomal Hex A/B with Ki value of 550 nM, suggesting that it is a selective inhibitor of OGA. In HEK293 cells, treatment of GlcNAcstatin at concentration of 20 nM resulted in increased cellular O-GlcNAc levels of many proteins. GlcNAcstatin also significantly prevented O-GlcNAc from binding to proteins in SH-SY5Y human neuroblastoma cell lysates [1, 2].
References
[1] Dorfmueller H, Borodkin V, Schimpl M, et al. GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation. Biochem. J, 2009, 420: 221-227.
[2] Dorfmueller H C, Borodkin V S, Schimpl M, et al. GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels. Journal of the American Chemical Society, 2006, 128(51): 16484-16485.
GlcNAcstatin Preparation Products And Raw materials
Raw materials
Preparation Products
GlcNAcstatin Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4679 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19696 | 58 |
Supplier | Advantage |
---|---|
Absin Bioscience Inc. | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 58 |
TargetMol Chemicals Inc. | 58 |