DOTA di(tBu)ester
- CAS No.
- 913542-71-9
- Chemical Name:
- DOTA di(tBu)ester
- Synonyms
- DOTA di(tBu)ester;Zaterol impurity 3;Gadobutrol Impurity 91;DOTA-bis(tert-butyl)ester;1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,7-bis(1,1-dimethylethyl) ester;2,2'-(4,10-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid
- CBNumber:
- CB65857245
- Molecular Formula:
- C24H44N4O8
- Molecular Weight:
- 516.63
- MDL Number:
- MOL File:
- 913542-71-9.mol
| Boiling point | 644.7±55.0 °C(Predicted) |
|---|---|
| Density | 1.133±0.06 g/cm3(Predicted) |
| pka | 3.94±0.10(Predicted) |
| FDA UNII | CQS4G43QCN |
DOTA di(tBu)ester Chemical Properties,Uses,Production
Uses
DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.
IC 50
RDC Bifunctional Chelator
DOTA di(tBu)ester Preparation Products And Raw materials
Raw materials
Preparation Products
DOTA di(tBu)ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
| Chemsigma International Co., Ltd. | +86-2558742998 +86-19951791336 | info@chemsigma.com | China | 1369 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | 0755-66853366; 13670046396 | ORDERS@QCSRM.COM | China | 24342 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 41457 | 60 |
| Shanghai Send Pharmaceutical Technology Co., Ltd. | 021-58088081 Q2816483246 | hailey@shsendpharm.com | China | 3095 | 55 |
| Quzhou AMK BioTech Co., Ltd | 0570-3081766 18357083060 | sales@qzamkbio.com | China | 982 | 55 |
| Shanghai GL Peptide Ltd. | +86-21-61263340; 17609490614 13764994101 | fisherwang@glschina.com | China | 8263 | 55 |
| ATK CHEMICAL COMPANY LIMITED | 021-51619050 13301662590 | mandy@atkchemical.com | China | 9109 | 55 |
| Grice Rand (Tianjin) Pharmaceutical Co., Ltd. | 022-83705301 13752403750 | 2966024760@qq.com | China | 839 | 55 |
| Changzhou Hopschain Chemical Co.,Ltd. | 0519-85528066 13775048983 | sales@hopschem.com | China | 31553 | 55 |