PYRIDINE-2-CARBOXAMIDE
- CAS No.
- 1452-77-3
- Chemical Name:
- PYRIDINE-2-CARBOXAMIDE
- Synonyms
- PICOLINAMIDE;2-PICOLINAMIDE;Picolinoylamide;PicolinaMide 98%;Picolinamide ,98%;2-Picolinamide>alpha-Picolinamide;TIMTEC-BB SBB008128;2-Carbamoylpyridine;Picolinic acid amide
- CBNumber:
- CB6713827
- Molecular Formula:
- C6H6N2O
- Molecular Weight:
- 122.12
- MDL Number:
- MFCD00023483
- MOL File:
- 1452-77-3.mol
- MSDS File:
- SDS
Melting point | 110 °C (dec.)(lit.) |
---|---|
Boiling point | 143 °C / 20mmHg |
Density | 1.2236 (rough estimate) |
refractive index | 1.5350 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | pK1: 2.10(+1) (20°C) |
form | Solid |
color | White to Off-White |
BRN | 109617 |
CAS DataBase Reference | 1452-77-3(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | I3550CCL59 |
EPA Substance Registry System | 2-Pyridinecarboxamide (1452-77-3) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-37/39 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29333990 | |||||||||
NFPA 704 |
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PYRIDINE-2-CARBOXAMIDE price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 104051 | Picolinamide 98% | 1452-77-3 | 10g | $49.8 | 2024-03-01 | Buy |
Sigma-Aldrich | 104051 | Picolinamide 98% | 1452-77-3 | 50g | $237 | 2024-03-01 | Buy |
TCI Chemical | P0414 | 2-Picolinamide >98.0%(HPLC)(T) | 1452-77-3 | 25g | $105 | 2024-03-01 | Buy |
Alfa Aesar | A15410 | Pyridine-2-carboxamide, 98% | 1452-77-3 | 5g | $43.65 | 2024-03-01 | Buy |
Alfa Aesar | A15410 | Pyridine-2-carboxamide, 98% | 1452-77-3 | 25g | $169.65 | 2024-03-01 | Buy |
PYRIDINE-2-CARBOXAMIDE Chemical Properties,Uses,Production
Chemical Properties
White to off-white solid
Uses
Picolinamide was used as template in preparation of molecular imprinting polymer. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO4.
Uses
A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.
Definition
ChEBI: A pyridinecarboxamide that is the monocarboxylic acid amide derivative of picolinic acid.
Biological Activity
picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor.parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.
Biochem/physiol Actions
Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Picolinamide acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates.
in vitro
the pathway of oxidation of picolinamide by a gram-negative rod has been elucidated. results showed that under high ph conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. in addition, whole cells were found to oxidize picolinamide, without lag. it was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate [1].
in vivo
picolinamide was used in a previous study to evaluate the possibility that the inhibition of na+/phosphate cotransport might be associated with the inhibition of nad hydrolyzing enzymes. results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit na+/phosphate cotransport by isolated renal brush border membrane vesicles. similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for na+/phosphate cotransport. unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical nad content after picolinamide treatment [2].
References
[1] c. g. orpin,m. knight, and w. c. evans. the bacterial oxidation of picolinamide, a photolytic product of diquatbiochem j. 1972 may; 127(5): 819–831.
[2] campbell pi, al-mahrouq ha,abraham mi,kempson sa. specific inhibition of rat renal na+/phosphate cotransport by picolinamide. j pharmacol exp ther.1989 oct;251(1):188-92.
PYRIDINE-2-CARBOXAMIDE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from PYRIDINE-2-CARBOXAMIDE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2023-10-14 | PYRIDINE-2-CARBOXAMIDE
1452-77-3
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
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2023-09-06 | PYRIDINE-2-CARBOXAMIDE
1452-77-3
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. | |
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2019-07-06 | PYRIDINE-2-CARBOXAMIDE
1452-77-3
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- PYRIDINE-2-CARBOXAMIDE
1452-77-3
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- PYRIDINE-2-CARBOXAMIDE
1452-77-3
- US $0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- PYRIDINE-2-CARBOXAMIDE
1452-77-3
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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