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4-tert-Octylphenol

4-tert-Octylphenol structure

CAS No.: 140-66-9

Chemical Name:: 4-tert-Octylphenol

Synonyms: Phenol, 4-(1,1,3,3-tetramethylbutyl)-;PTOP;4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL;PARA-TERT-OCTYLPHENOL;p-octylphenol;P-T-OCTYL PHENOL;NSC 5427;NSC 7248;p-(tert-octyL;4-t-Octylphenol

CBNumber:: CB6724049

Molecular Formula:: C14H22O

Molecular Weight:: 206.32

MDL Number:: MFCD00002368

MOL File:: 140-66-9.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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4-tert-Octylphenol Properties

Melting point	79-82 °C(lit.)
Boiling point	175 °C30 mm Hg(lit.)
Density	0.95 g/cm3 (20℃)
vapor pressure	2Pa at 38℃
refractive index	1.5003 (estimate)
Flash point	145 °C
storage temp.	-20°C
solubility	water: slightly soluble0.007g/L at 20°C
pka	10.15±0.15(Predicted)
form	Solid
color	White flakes
PH Range	6 at 10 g/l at 20 °C
Water Solubility	7mg/L at 20℃
BRN	513992
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
LogP	4.8 at 22℃
CAS DataBase Reference	140-66-9(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	ALPHA-{P-(1,1,3,3-TETRAMETHYLBUTYL)PHENYL}-OMEGA-HYDROXYPOLY(OXYETHYLENE)
FDA 21 CFR	175.300
EWG's Food Scores	4
FDA UNII	IOY9FVU3J3
NIST Chemistry Reference	Phenol, 4-(1,1,3,3-tetramethylbutyl)-(140-66-9)
EPA Substance Registry System	p-(1,1,3,3-Tetramethylbutyl)phenol (140-66-9)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS09

Signal word

Danger

Hazard statements

H315-H318-H410

Precautionary statements

P264-P273-P280-P302+P352-P305+P351+P338-P332+P313

Hazard Codes

Xn,N,Xi,F

Risk Statements

21-38-41-50/53-67-66-36-11-52/53-68-62-40

Safety Statements

26-36-61-60-39-16-9

RIDADR

2430

WGK Germany

RTECS

SM9625000

HazardClass

PackingGroup

III

HS Code

29071300

Hazardous Substances Data

140-66-9(Hazardous Substances Data)

NFPA 704

	1
2		0

4-tert-Octylphenol price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	442858	4-tert-Octylphenol analytical standard	140-66-9	500mg	$52.6	2024-03-01	Buy
Sigma-Aldrich	290823	4-tert-Octylphenol 97%	140-66-9	25g	$52.8	2024-03-01	Buy
Sigma-Aldrich	290823	4-tert-Octylphenol 97%	140-66-9	1kg	$208	2024-03-01	Buy
TCI Chemical	T0144	4-(1,1,3,3-Tetramethylbutyl)phenol >95.0%(GC)	140-66-9	25g	$23	2024-03-01	Buy
TCI Chemical	T0144	4-(1,1,3,3-Tetramethylbutyl)phenol >95.0%(GC)	140-66-9	500g	$41	2024-03-01	Buy

Product number	Packaging	Price	Buy
442858	500mg	$52.6	Buy
290823	25g	$52.8	Buy
290823	1kg	$208	Buy
T0144	25g	$23	Buy
T0144	500g	$41	Buy

4-tert-Octylphenol Chemical Properties,Uses,Production

Chemical Properties

white powder

Uses

4-tert-Octylphenol (4t-OP) is used in manufacturing processes as an intermediate in the generation of surfactants, synthetic rubber additives, or resins. 4t-OP is also used to manufacture alkylphenol ethoxylates. It is found mainly in detergents, cleaning products, and emulsifiers and less frequently in paints, personal care products, pesticides, paper, pulp, and textiles.

Definition

ChEBI: 4-tert-Octylphenol is an alkylbenzene.

General Description

4-tert-Octylphenol is a potential environmental pollutant and it exhibits toxic and estrogenic effects on mammalian cells. It binds to estrogen receptors and exerts estrogenic actions in vitro. The transformation of the 4-tert-octylphenol upon irradiation at 253.7nm and by hydroxyl radicals generated by the photolysis (λ_exc = 253.7nm) of hydrogen peroxide in aqueous solution has been studied.

Health effects

4-tert-octylphenol (OP) is an endocrine-disrupting chemical that causes harmful effects to human health.a common environmental pollutant showing weak estrogenic effects. 4-tert-Octylphenol has been shown to cause harm to the male reproductive system of vertebrates.
High doses of several alkylphenols, including 4- tert-octylphenol, have altered estrogenic effects, including sex hormone levels, estrus cycles, reproductive outcomes, neonatal sexual development, as well as impaired production of steroid hormone and testicular atrophy.

Environmental Fate

Studies have shown that 4t-OP will adsorb to sediments.

Purification Methods

Crystallise the phenol from n-hexane and/or distil it in a vacuum. [Beilstein 6 III 2051, 6 IV 3484.]

Toxicity evaluation

4t-OP has been shown to be an estrogen receptor (ER) agonist. Estrogenic effects of 4t-OP have been demonstrated in human cells, with 4t-OP displacing the natural estrogen 17b estradiol from its receptor, and 4t-OP inducing cell proliferation in estrogen-dependent cell proliferation assays. In vivo confirmation of 4t-OP’s estrogenicity has been confirmed with the uterotrophic assay.

4-tert-Octylphenol synthesis

Synthesis of 4-tert-Octylphenol from Carbamic acid, N,N'-1,6-hexanediylbis-, C,C'-bis[4-(1,1,3,3-tetramethylbutyl)phenyl] ester

4-tert-Octylphenol Preparation Products And Raw materials

Raw materials

Phenol Polyisobutylene 2,4,4-TRIMETHYL-2-PENTENE

Preparation Products

octyl phenyl polyoxyethylene (30) ether emulsifier SOPE-6 POLYETHYLENE GLYCOL TERT-OCTYLPHENYL ETHER pesticide emulsifier 700^<#^> emulsifier SOPE-4

emulsifier SOPE-7 emulsifier SOPE-20 Bromoxynil emulsifier SOPE-10 octyl phenyl polyoxyethylene (3) ether

HEXAETHYLENE GLYCOL MONOOCTYL ETHER emulsifier SOPE-15 complex polyalkyl phenol polyoxyethylene ether Benzethonium chloride Acid Violet 48

Disperse Red 165 1-[2-(2-chloroethoxy)ethoxy]-4-(1,1,3,3-tetramethylbutyl)benzene 2-CHLORO-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL

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4-tert-Octylphenol Suppliers

Global( 410)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HANGZHOU HAILAN CHEMICAL CO.,LTD.	+86-57156122185 +86-15967590394	sales@hailan-chem.com	China	297	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12806	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	3005	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20233	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
Tianjin Zhongxin Chemtech Co., Ltd.	86-22-66880623 +8618622897568	sales@tjzxchem.com	China	572	58

Supplier	Advantage
HANGZHOU HAILAN CHEMICAL CO.,LTD.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Kingfiner Technology Development Co.Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Tianjin Zhongxin Chemtech Co., Ltd.	58

View Lastest Price from 4-tert-Octylphenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-27	4-tert-Octylphenol 140-66-9	US $0.00 / removed		99.79%	10g	TargetMol Chemicals Inc.
2025-04-23	4-tert-Octylphenol 140-66-9	US $1.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-15	4-Tert-Octylphenol 140-66-9	US $120.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co.,Ltd

4-tert-Octylphenol
140-66-9
US $0.00 / removed
99.79%
TargetMol Chemicals Inc.

4-tert-Octylphenol
140-66-9
US $1.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Tert-Octylphenol
140-66-9
US $120.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

4-tert-Octylphenol Spectrum

4-tert-Octylphenol(140-66-9)MS 4-tert-Octylphenol(140-66-9)¹HNMR 4-tert-Octylphenol(140-66-9)¹³CNMR 4-tert-Octylphenol(140-66-9)IR1 4-tert-Octylphenol(140-66-9)IR2 4-tert-Octylphenol(140-66-9)IR3 4-tert-Octylphenol(140-66-9)Raman

140-66-9(4-tert-Octylphenol )Related Search:

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Potassium heptadecafluoro-1-octanesulfonate 3-Aminophenol 2-Aminophenol Triton X-100 PARA-TERT-OCTYLPHENOL,PARA-TERT-OCTYLPHENOL,P-TERT-OCTYLPHENOL,PARA-TERT-OCTYLPHENOL,P-TERT-OCTYLPHENOL,OCTYLPHENOL

5,5',6,6'-TETRAHYDROXY-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBISINDANE 2-(2-HYDROXY-5-TERT-OCTYLPHENYL)BENZOTRIAZOLE Octafonium chloride

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4-TERT-OCTYLPHENOL 4-(DI-ISO-BUTYL) PHENOL P-TERT-OCTYLPHENOL P-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL P-(1,1,3,3-TETRAMETHYL-N-BUTYL)PHENOL 4-TERT-OCTYLPHENOL, 500MG,NEAT paraTertiary Octyl Phenol Iso-OctylPhenoxyPolyethoxyEthanol(TritonX-100) 4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL APPROX. 90% 4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL 93+% 4-t-Octylphenol Phenol, 4-(1,1,3,3-tetramethyl-buthyl)- 4-tert-Octylphenol (same as S-4378-1-5T) P-tert-Octylphenol 5g [140-66-9] 4-tert-Octylphenol,4-(1,1,3,3-Tetramethylbutyl)phenol PHENOL,4-(1,1,3,3-TETRAMETHYL 1-hydroxy-4-octylbenzene NSC 5427 NSC 7248 4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL FOR S p-(1,1,3,3-tetramethylbutyl)-pheno p-(1’,1’,3’,3’-tetramethylbutyl)fenol p-(tert-octyl)-pheno Phenol, p-(1,1,3,3-tetramethylbutyl)- Phenol, p-(tert-octyl)- phenol,-(1,1,3,3-tetramethylbutyl)- p-Terc.oktylfenol p-terc.oktylfenol(czech) TIMTEC-BB SBB008090 OfTERT octylphenol 4-tert-Octylphenol 97% For Te Xinji phenol (POP) 4-|tert|-Octylphenol (POP) 4-tert-Octylphenol solution 4-(1,1,3,3-Tetramethylbutyl)phenol for synthesis 4-(1,1,3,3-tetramethylbutyl)-pheno p-(tert-octyL 4-tert-OctyphenolSolution,1,000mg/L,1ml p-n-Octylphenol Standard 4-tert-Octylphenol@100 μg/mL in Methanol 4-(1,1,3,3-Tetramethylbutyl)phenol > P-teroctyl phenol 4-tert-Octylphenol solution in Acetonitrile，1000ug/ml 4-tert-Octylphenol ISO 9001：2015 REACH 4-tert-Octylphenol 140-66-9 4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL P-T-OCTYL PHENOL PARA-TERT-OCTYLPHENOL Phenol, 4-(1,1,3,3-tetramethylbutyl)- p-octylphenol PTOP 4-tert-Octylphenol Manufacturer/High quality/Best price/In stock CAS NO.140-66-9 C15712100 4-tert-Octylphenol 4-tert.-Octylphenol in Methanol 4-tert-Octylphenol 4-tert-Octylphenol solution 140-66-9 CH33CCH2CCH32C6H4OH