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Cefonicid sodium

CAS No.
61270-78-8
Chemical Name:
Cefonicid sodium
Synonyms
SKF D-75073-Z2;Monocid sodium;CEFONICID SODIUM;Cefonicid sodiumr;CEFONICID DISODIUM;Cefonicid Sodium (1 g);CEFONICID DISODIUM SALT;Cefonicid (sodium salt);CefonicidSodium(Sterile);Cefonicid sodium USP/EP/BP
CBNumber:
CB6743497
Molecular Formula:
C18H19N6NaO8S3
Molecular Weight:
566.55
MDL Number:
MFCD00941437
MOL File:
61270-78-8.mol
Last updated:2024-11-04 20:04:50

Cefonicid sodium Properties

Melting point > 160°C
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Pale Yellow
CAS DataBase Reference 61270-78-8(CAS DataBase Reference)
FDA UNII F74MFL78A1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501
HS Code  2941906000

Cefonicid sodium price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18745 Cefonicid (sodium salt) ≥98% 61270-78-8 100mg $44 2024-03-01 Buy
Cayman Chemical 18745 Cefonicid (sodium salt) ≥98% 61270-78-8 500mg $193 2024-03-01 Buy
Cayman Chemical 18745 Cefonicid (sodium salt) ≥98% 61270-78-8 1g $341 2024-03-01 Buy
TRC C242878 CefonicidSodium 61270-78-8 10mg $45 2021-12-16 Buy
Biosynth Carbosynth FC50064 Cefonicid sodium 61270-78-8 1g $60 2021-12-16 Buy
Product number Packaging Price Buy
18745 100mg $44 Buy
18745 500mg $193 Buy
18745 1g $341 Buy
C242878 10mg $45 Buy
FC50064 1g $60 Buy

Cefonicid sodium Chemical Properties,Uses,Production

Description

Cefonicid sodium is the first of the second-generation cephalosporin antibiotics with a long enough serum half-life b4.5 hr.) to allow once-daily i.v. administration. Cefonicid is resistant to β-lactamases produced by S. aureus, H. influenzae, -N. gonorrhea, and related organisms. As with other drugs of this class, it is useful in the treatment of urinary tract and lower respiratory tract infections, skin and skin structure infections, and bone and joint infections, as well as in surgical prophylaxis.

Description

Cefonicid is a second-generation cephalosporin antibiotic. Like other cephalosporins, cefonicid interferes with cell wall biosynthesis in bacteria, leading to lysis of the infectious organism. It is a broad-spectrum antibiotic and has a prolonged serum elimination half-life in animals.

Chemical Properties

White Powder

Originator

Smith Kline & French (USA)

Uses

A semi-synthetic cephalosporin antibiotic related to Cefamandole. Antibacterial.

Definition

ChEBI: Cefonicid sodium is an organic sodium salt. It contains a cefonicid(2-).

brand name

MONOCID

Clinical Use

Cefonicid Sodium (Monocid) is a second-generationcephalosporin that is structurally similar to cefamandole,except that it contains a methane sulfonic acid groupattached to the N-1 position of the tetrazole ring. Theantimicrobial spectrum and limited β-lactamase stabilityof cefonicid are essentially identical with those ofcefamandole.
Cefonicid is unique among the second-generationcephalosporins in that it has an unusually long serum halflifeof approximately 4.5 hours. High plasma protein bindingcoupled with slow renal tubular secretion are apparentlyresponsible for the long duration of action. Despite the high fraction of drug bound in plasma, cefonicid is distributedthroughout body fluids and tissues, with the exception of thecerebrospinal fluid.
Cefonicid is supplied as a highly water-soluble disodiumsalt, in the form of a sterile powder to be reconstituted forinjection. Solutions are stable for 24 hours at 25°C and for72 hours when refrigerated.

in vitro

cefonicid was found to be similar to cefamandole in its superiority to first generation cephalosporins against several enterobacteriaceae and haemophilus influenzae, such as beta-lactamase-producing strains. its activity against staphylococcus aureus was similar to that of cefoxitin and inferior to cefamandole and first generation cephalosporins. cefonicid has excellent in-vitro activity against neisseria gonorrhoeae, but is inactive against pseudomonas, serratia, acinetobacter, and bacteroides fragilis [1].

in vivo

the purpose of a previous study was to determine whether cefonicid caused testicular toxicity when subcutaneously administered to sprague-dawley male rats at doses of 50 to 1,000 mg/kg per day. the histological findings were confirmed by marked reductions in testicular sperm production rates and cauda epididymal sperm numbers. in addition, cefonicid had no treatment-related adverse effects on the sexual maturation males [2].

References

[1] saltiel, e; brogden, r. n. (1986). cefonicid. a review of its antibacterial activity, pharmacological properties and therapeutic use. drugs. 32 (3): 222–59.
[2] manson jm, zolna le, kang yj, johnson cm. effects of cefonicid and other cephalosporin antibiotics on male sexual development in rats. antimicrob agents chemother. 1987 jul;31(7):991-7.

Cefonicid sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 168)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850 hbjbtech@163.com China 1000 58
Hebei Saisier Technology Co., LTD
+86-18400010335 +86-18034520335 admin@hbsaisier.cn China 1015 58
Hebei Longbang Technology Co., LTD
+86-18633929156 +86-18633929156 admin@hblongbang.com China 941 58
HebeiShuoshengImportandExportco.,Ltd
+86-18532138899 +86-18532138899 L18532138899@163.com China 939 58
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29885 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845 sales@amoychem.com China 6383 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17365 58
Hebei Runbin Biotechnology Co. LTD
13180553332 2179877681@qq.com CHINA 990 58

View Lastest Price from Cefonicid sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cefonicid sodium pictures 2024-11-08 Cefonicid sodium
61270-78-8
US $6.00 / kg 1kg 99% 2000KG/Month HebeiShuoshengImportandExportco.,Ltd
Cefonicid sodium pictures 2024-11-07 Cefonicid sodium
61270-78-8
US $6.00 / kg 1kg More than 99% 2000KG/Month Hebei Longbang Technology Co., Ltd
Cefonicid sodium pictures 2024-11-07 Cefonicid sodium
61270-78-8
US $8.00 / kg 1kg 99% 200000 Hebei Jingbo New Material Technology Co., Ltd
  • Cefonicid sodium pictures
  • Cefonicid sodium
    61270-78-8
  • US $6.00 / kg
  • More than 99%
  • Hebei Longbang Technology Co., Ltd
  • Cefonicid sodium pictures
  • Cefonicid sodium
    61270-78-8
  • US $8.00 / kg
  • 99%
  • Hebei Jingbo New Material Technology Co., Ltd

Cefonicid sodium Spectrum

disodium (6r,7r)-7-[[(2r)-2-hydroxy-2-phenyl-acetyl]amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate CEFONICID DISODIUM CEFONICID SODIUM 5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[(HYDROXYPHENYLACETYL)AMINO]-8-OXO-3-[[[1-(SULFOMETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-, DISODIUM SALT CEFONICID SODIUM[5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[(HYDROXYPHENYLACETYL)AMINO]-8-OXO-3-[[[1-(SULFOMETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-, DISODIUM SALT] CEFONICID DISODIUM SALT CefonicidDisodiumC18H16N6Na2O8S3 CefonicidSodium(Sterile) (6R,7R)-7α-[[(R)-Hydroxyphenylacetyl]amino]-8-oxo-3-[[[1-(sodiooxysulfonylmethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt SKF D-75073-Z2 Cefonicid Sodium (1 g) (COLD SHIPMENT REQUIRED) Cefonicid Sodium (1 g) Cefonicid (sodium salt) Monocid sodium sodium (6R,7R)-7-((R)-2-hydroxy-2-phenylacetamido)-8-oxo-3-(((1-(sulfonatomethyl)-1H-tetrazol-5-yl)thio)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Cefonicid sodium USP/EP/BP Cefonicid sodiumr Cefonicid Sodium (COLD SHIPMENT REQUIRED) (1097750) 61270-78-8 156-1-48 99-0-4 C18H16N6Na2O8S3 C18H16N6O8S32Na C18H18N6Na2O8S3