ANTI-CASPASE-3
- CAS No.
- Chemical Name:
- ANTI-CASPASE-3
- Synonyms
- Anti-SCA1;ANTI-LICE;ANTI-YAMA;ANTI-CASP3;ANTI-ICE-3;ANTI-CPP32;Anti-CPP32B;ANTI-APOPAIN;ANTI-CASPASE-3;ANTI-HUMAN CPP32
- CBNumber:
- CB6750242
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01321906
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H312-H412 |
Precautionary statements | P273-P280-P302+P352+P312-P362+P364-P501 |
WGK Germany | 3 |
ANTI-CASPASE-3 price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SAB4503291 | Anti-CASP3 antibody produced in rabbit affinity isolated antibody | 100μg | $506 | 2024-03-01 | Buy | |
Sigma-Aldrich | HPA002643 | Anti-CASP3 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 100μL | $514 | 2024-03-01 | Buy | |
Sigma-Aldrich | C8487 | Anti-Caspase 3, Active antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 25μL | $174 | 2024-03-01 | Buy | |
Sigma-Aldrich | C9598 | Anti-Caspase 3 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 0.2mL | $313.8 | 2024-03-01 | Buy | |
Sigma-Aldrich | C8487 | Anti-Caspase 3, Active antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 100μL | $499 | 2024-03-01 | Buy |
ANTI-CASPASE-3 Chemical Properties,Uses,Production
Uses
Anti-Caspase 3, Active antibody has been used:
- for western blotting of cytochrome c for caspase activation
- as primary antibody in immunofluorescence staining of embryos and postnatal mice cryosections
- in Western blot analysis of activated caspase 3
- as a primary antibody in immunodetection of rat brain sections
General Description
Caspase-3 (CASP3) belongs to the class of cysteine proteases. CASP3?is an executioner caspase, which is cleaved and activated with the help of caspase-8 and caspase-9 initiator caspases. CASP3?is mapped to human chromosome 4q35.1.
Biochem/physiol Actions
Caspase 3 is one of the key effectors of apoptosis. It acts downstream of caspase 9 in the apoptotic pathway. During apoptosis, it gets activated by proteolytic cleavage into the 17-19 kDa (p17, p18) and 12 kDa (p12) active subunits. Any alteraion in CASP-3 in mice, causes premature lethality. It has also shown that the deletion of gene affects brain development resulting of hyperplasias and disorganized cell deployement. Clinically it is related to Huntington disease (HD). Caspase 3 brings about cell death by activating CAD (caspase activated DNAse I), an endonuclease that causes degradation of chromosomal DNA.
ANTI-CASPASE-3 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-CASPASE-3 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Bohu Biotechnology Co., LTD | 021-57763112 13585886131 | 3004987436@qq.com | China | 9694 | 58 |
Supplier | Advantage |
---|---|
Sigma-Aldrich | 80 |
Shanghai Bohu Biotechnology Co., LTD | 58 |