3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID
- CAS No.
- 179528-45-1
- Chemical Name:
- 3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID
- Synonyms
- CS-2366;PD 150606;PD150606 (PD 150606;PD150606;PD-150606;PD 150606;(Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid;(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid;3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID;(Z)-3-(4-IODOPHENYL)-2-SULFANYLPROP-2-ENOIC ACID;(2Z)-3-(4-iodophenyl)-2-mercapto-2-Propenoic acid;(2Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid
- CBNumber:
- CB6767143
- Molecular Formula:
- C9H7IO2S
- Molecular Weight:
- 306.12
- MDL Number:
- MFCD00949076
- MOL File:
- Mol file
- MSDS File:
- SDS
| Boiling point | 410.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.901±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >20mg/mL |
| pka | 2.98±0.10(Predicted) |
| form | powder |
| color | yellowish |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H317-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-37/38-41-43 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| NFPA 704 |
|
3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D5946 | PD 150606 ≥97% (HPLC) | 179528-45-1 | 5mg | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | D5946 | PD 150606 ≥97% (HPLC) | 179528-45-1 | 25mg | $505 | 2024-03-01 | Buy |
| Cayman Chemical | 13859 | PD 150606 ≥98% | 179528-45-1 | 5mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 13859 | PD 150606 ≥98% | 179528-45-1 | 25mg | $332 | 2024-03-01 | Buy |
| Tocris | 1269 | PD 150606 ≥95%(HPLC) | 179528-45-1 | 10 | $173 | 2021-12-16 | Buy |
3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID Chemical Properties,Uses,Production
Description
PD-150606 (179528-45-1) is a selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices.1 PD-150606 displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death.2 Some protective effects may be due to inhibition of MMP activity.3
Uses
PD 150606 is a novel mercaptoacrylate based compound and a potent inhibitor of Ca2+-dependent activation of calpain-1, a Ca2+-activated cytosolic cysteine protease. PD 150606 may potentially be developed as an anti-inflammatory agent. Neuroprotective product.
Definition
ChEBI: An organoiodine compound that is acrylic acid in which the vinylic hydrogens at positions 2 and 3 are replaced by mercapto and 4-iodophenyl groups respectively (the Z geoisomer).
Biochem/physiol Actions
PD 150606 is a selective; cell-permeable; non-peptide; uncompetitive calpain inhibitor.
storage
Store at -20°C
References
1) Wang?et al. (1996),?An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective; Proc. Natl. Acad. Sci. USA,?93?6687 2) Waters?et al. (1997),?Calpains mediate calcium and chloride influx during the late phase of cell injury; J. Pharmacol. Exp. Therap.,?283?1177 3) Ali?et al. (2012), Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity; Biochem. Biophys. Res. Commun.,?423?1
3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94657 | 76 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14055 | 65 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8065 | 58 |
