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BDTX-189

BDTX-189 Structure
BDTX-189 structure
CAS No.
2414572-47-5
Chemical Name:
BDTX-189
Synonyms
BDTX-189;Bugatinib;Tuxobertinib;Tuxobertinib (BDTX-189);Tuxobertinib, 10 mM in DMSO;EGFR/HER2 inhibitor BDTX-189;ErbB mutant-specific inhibitor BDTX-189;N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-(2-morpholinoethoxy)quinazolin-6-yl)acrylamide;2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl]-;Tuxobertinib,inhibit,ErbB-1,EGFR,BDTX 189,BDTX189,mutants,Epidermal growth factor receptor,nude,allosteric,Ba/F3,HER1,oncogene athymic,oral,mice,insertion,Inhibitor
CBNumber:
CB68117755
Molecular Formula:
C29H29ClN6O4
Molecular Weight:
561.03
MDL Number:
MFCD32878264
MOL File:
2414572-47-5.mol
Last updated:2025-04-17 18:22:24
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BDTX-189 Properties

Boiling point 778.0±60.0 °C(Predicted)
Density 1.349±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:22.56(Max Conc. mg/mL);40.21(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);1.78(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.53(Max Conc. mM)
form A solid
pka 12.20±0.43(Predicted)
color Off-white to light yellow
FDA UNII 6CE2107J4T

BDTX-189 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0133688 BDTX-189 99.94% 2414572-47-5 5mg $450 2021-12-16 Buy
ChemScene CS-0133688 BDTX-189 99.94% 2414572-47-5 10mg $750 2021-12-16 Buy
ChemScene CS-0133688 BDTX-189 99.94% 2414572-47-5 25mg $1450 2021-12-16 Buy
ChemScene CS-0133688 BDTX-189 99.94% 2414572-47-5 50mg $2250 2021-12-16 Buy
ChemScene CS-0133688 BDTX-189 99.94% 2414572-47-5 100mg $3350 2021-12-16 Buy
Product number Packaging Price Buy
CS-0133688 5mg $450 Buy
CS-0133688 10mg $750 Buy
CS-0133688 25mg $1450 Buy
CS-0133688 50mg $2250 Buy
CS-0133688 100mg $3350 Buy

BDTX-189 Chemical Properties,Uses,Production

Uses

Tuxobertinib (BDTX-189) is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. Tuxobertinib shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity[1].

in vivo

Tuxobertinib (0-100 mg/kg; p.o.; daily for 15 dyas) shows dose-dependent tumor growth inhibition and regression in in athymic nude mice bearing HER2 S310F Ba/F3 allograft tumors[1].
? Tuxobertinib (1-50 mg/kg.p.o.; daily for 15 days) shows dose-dependent tumor growth inhibition and regression in athymic nude mice bearing CUTO-14 PDX tumors that express the EGFR mutation EGFR ASV[1].

IC 50

EGFR: 0.2 nM (Kd); HER2: 0.76 nM (Kd); RIPK2: 1.2 nM (Kd); BLK: 13 nM (Kd)

References

[1] Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.

BDTX-189 Preparation Products And Raw materials

Raw materials

Preparation Products

BDTX-189 Suppliers

Global( 72)Suppliers
Supplier Tel Email Country ProdList Advantage
HangZhou RunYan Pharma Technology Co.,LTD. 		+8618882027439 sales2@runyanpharma.com China 302 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32202 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38636 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3512 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Supplier Advantage
HangZhou RunYan Pharma Technology Co.,LTD. 		58
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Hebei Miaoyin Technology Co.,Ltd 		58
Aladdin Scientific 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58

View Lastest Price from BDTX-189 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BDTX-189; Tuxobertinib pictures 2025-04-28 BDTX-189; Tuxobertinib
2414572-47-5
 US $0.00-0.00 / MG 10MG 99% HPLC 10000 HangZhou RunYan Pharma Technology Co.,LTD.
Tuxobertinib pictures 2024-11-18 Tuxobertinib
2414572-47-5
 US $34.00-97.00 / mg 98.86% 10g TargetMol Chemicals Inc.
  • Tuxobertinib pictures
  • Tuxobertinib
    2414572-47-5
  • US $34.00-97.00 / mg
  • 98.86%
  • TargetMol Chemicals Inc.
BDTX-189 2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl]- Tuxobertinib Tuxobertinib,inhibit,ErbB-1,EGFR,BDTX 189,BDTX189,mutants,Epidermal growth factor receptor,nude,allosteric,Ba/F3,HER1,oncogene athymic,oral,mice,insertion,Inhibitor EGFR/HER2 inhibitor BDTX-189 ErbB mutant-specific inhibitor BDTX-189 Tuxobertinib (BDTX-189) Bugatinib N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-(2-morpholinoethoxy)quinazolin-6-yl)acrylamide Tuxobertinib, 10 mM in DMSO 2414572-47-5 C29H29ClN6O4 API APIs