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SD-36

SD-36 Structure
SD-36 structure
CAS No.
2429877-44-9
Chemical Name:
SD-36
Synonyms
SD-36;P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethyl]phosphonic acid;Phosphonic acid, P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethyl]-;Phosphonic acid, P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethy...
CBNumber:
CB68190619
Molecular Formula:
C59H62F2N9O12P
Molecular Weight:
1158.17
MDL Number:
MFCD32263414
MOL File:
2429877-44-9.mol
Last updated:2025-04-17 18:22:24
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SD-36 Properties

Density 1.50±0.1 g/cm3(Predicted)
pka 1.75±0.10(Predicted)
form Solid
color White to off-white

SD-36 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
1Pluschem 1P01KAKD Phosphonic acid, P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethy... 95% 2429877-44-9 25mg $1631 2021-12-16 Buy
1Pluschem 1P01KAKD Phosphonic acid, P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethy... 95% 2429877-44-9 100mg $4008 2021-12-16 Buy
Product number Packaging Price Buy
1P01KAKD 25mg $1631 Buy
1P01KAKD 100mg $4008 Buy

SD-36 Chemical Properties,Uses,Production

Uses

SD-36 is a potent, selective and efficacious PROTAC (proteolysis targeting chimera) degrader of STAT3 (Signal transducer and activator of transcription 3) protein.

in vivo

SD-36 (25-100 mg/kg; i.v.; weekly dosing for 4 weeks) achieves complete and long-lasting tumor regression in mice[1].
SD-36 effectively inhibits tumor growth at 25 and 50 mg/kg administered on day 1, 3, and 5 per week and achieved complete tumor regression at 100 mg/kg with the same schedule in the SU-DHL-1 xenograft model[1].
SD-36 at 50 mg/kg 3 times per week completely inhibits tumor growth in the SUP-M2 tumor model[1].

Animal Model:SCID female mice (MOLM-16 xenograft model)[1]
Dosage:25, 50, 100 mg/kg
Administration:i.v.; weekly dosing for 4 weeks
Result:At 25 and 50 mg/kg weekly dosing for 4 weeks effectively inhibited tumor growth. At either 100 mg/kg weekly or 50 mg/kg twice weekly for 4 weeks induced complete tumor regression.

IC 50

STAT3: 50 nM (Kd); Cereblon

SD-36 Preparation Products And Raw materials

Raw materials

Preparation Products

SD-36 Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7787 56
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 10499 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1592 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 021-58461859 15821823057 service@aiviche.com China 49312 58
Guangzhou Younan Technology Co., Ltd 020-82000279 18988968278 YN_research@163.com China 2869 58
Nanjing Shizhou Biotechnology Co., Ltd 025-85563444 15850508050 rose.shi@synzest.com China 271 58
Wuhan Topule +86-02787215551 +86-19945035818 2936752263@qq.com China 8081 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai SuperLan Chemcial Technique Centre 58
Jilin Province Woda Biotechnology Co., Ltd. 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 58
Guangzhou Younan Technology Co., Ltd 58
Nanjing Shizhou Biotechnology Co., Ltd 58
Wuhan Topule 58
P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethyl]phosphonic acid Phosphonic acid, P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethy... SD-36 Phosphonic acid, P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethyl]- 2429877-44-9 C59H62F2N9O12P