Rifamycin Sodium
- CAS No.
- 14897-39-3
- Chemical Name:
- Rifamycin Sodium
- Synonyms
- Rifamycin SV s;RIFAMYCIN SODIUM;Rifamycinsodiumsal;RIFAMYCIN SV-SODIUM;RIFAMPICIN SV SODIUM;Rifamycin sodium CRS;rifamycin sodium salt;Rifamycin Na USP/EP/BP;Rifamycin SV Monosodium;RIFAMYCIN SV SODIUM SALT
- CBNumber:
- CB6854850
- Molecular Formula:
- C37H48NNaO12
- Molecular Weight:
- 721.78
- MDL Number:
- MFCD00056847
- MOL File:
- 14897-39-3.mol
- MSDS File:
- SDS
| Melting point | >215°C (dec.) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | ethanol: soluble50mg/mL |
| form | powder |
| color | Dark Red |
| Water Solubility | Soluble in water, alcohol and dimethyl sulfoxide. |
| Merck | 13,8302 |
| FDA UNII | 32086GS35Z |
| UNSPSC Code | 51283601 |
| NACRES | NA.76 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | KD1922500 |
| F | 8-10-23 |
Rifamycin Sodium price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R8626 | Rifamycin SV sodium salt potency: ≥900units (dry basis) | 14897-39-3 | 1g | $119 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR1664 | Rifamycin sodium Pharmaceutical Secondary Standard; Certified Reference Material | 14897-39-3 | 500mg | $137 | 2024-03-01 | Buy |
| Alfa Aesar | J63095 | Rifamycin SV sodium, 98+% | 14897-39-3 | 1g | $102 | 2024-03-01 | Buy |
| Alfa Aesar | J63095 | Rifamycin SV sodium, 98+% | 14897-39-3 | 5g | $372 | 2024-03-01 | Buy |
| Cayman Chemical | 21441 | Rifamycin SV (sodium salt) ≥98% | 14897-39-3 | 500mg | $30 | 2021-12-16 | Buy |
Rifamycin Sodium Chemical Properties,Uses,Production
Chemical Properties
Dark Red Solid
Uses
Semi-synthetic antibiotic derived from Rifamycin S. Antibacterial. Potency >900 units (dry basis).
Uses
Rifamycin SV Sodium (Rifaximin EP Impurity C) is a semi-synthetic antibiotic derived from Rifamycin S. (1) Antibacterial (2). Potency >900 units (dry basis).
Biological Activity
Rifamycin SV inhibits selective (E. coli, B. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunit, a mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.
in vivo
Rifamycin (5 mg/day; s.c.; 3 days a week) sodium is effective in mice infected with M. tuberculosis, significantly reducing the number of viable bacteria in the body[4].
Rifamycin (12.5-25 mg/kg; peritoneal lavage) sodium can improve the survival rate of rats with experimental intraperitoneal infection and significantly reduce the number of intraperitoneal bacteria and adhesion formation[6].
Rifamycin (5-40 mg/kg; esophageal gavage; once a day, 5 days a week; 4 weeks) sodium shortens oral treatment duration in a mouse model of Mycobacterium ulcerans disease[8].
Rifamycin (0.1 mL; intraaural administration; twice daily; 10 days) sodium does not cause hearing loss in adult or weanling rats[9].
Rifamycin (1 mg i.v. bolus followed by 4 mg i.v. infusion; 70 min) sodium interferes with three major steps of Bile acid metabolism in rats with intravenous Sodium cholate (HY-N0324A) infusion, resulting in a significant decrease in bile acid uptake and excretion[10].
Rifamycin (10-160 mg/kg; s.c.; single dose) sodium is approximately 11 times less effective than Metronidazole (HY-B0318) in a mouse Bacteroides fragilis thigh infection model[11].
| Animal Model: | Male Wistar rats (weight 200-250 g), cecal ligation puncture (CLP)-induced intra-abdominal infection model[6] |
| Dosage: | 25 mg/kg, 12.5 mg/kg |
| Administration: | Peritoneal lavage |
| Result: | Improved survival from 50% in the control group to 91.7% in the 25 mg/kg group and 100% in the 12.5 mg/kg group. Significantly reduced adhesion formation. Showed a greater reduction in bacterial counts in peritoneal fluid (25 mg/kg). |
Rifamycin Sodium Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 | sales@suikangpharm.com | China | 311 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29859 | 58 |
| Zhengzhou Yuanli Biological Technology Co., Ltd | 0086-371-67897870 18903711767 | sales02@zzyuanli.cn | CHINA | 149 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
View Lastest Price from Rifamycin Sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-24 | Rifamycin Sodium
14897-39-3
|
US $0.00-0.00 / Kg/Drum | 1KG | 98%min | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-23 | Rifamycin Sodium
14897-39-3
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-18 | Rifamycin sodium salt
14897-39-3
|
US $0.00-0.00 / g | 100g | 910u/mg | 25kgs | Cangzhou Kangrui Pharma Tech Co. Ltd., |
-
- Rifamycin Sodium
14897-39-3
- US $0.00-0.00 / Kg/Drum
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Rifamycin Sodium
14897-39-3
- US $1.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Rifamycin sodium salt
14897-39-3
- US $0.00-0.00 / g
- 910u/mg
- Cangzhou Kangrui Pharma Tech Co. Ltd.,
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