Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]-

Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]-

Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]- Structure
Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]- structure
CAS No.
1838123-22-0
Chemical Name:
Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]-
Synonyms
(R,R)-CXCR2-IN-2;(R,R) CXCR2 IN 2,(R,R)CXCR2IN2,(R,R)-CXCR-2-IN-2;Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]-
CBNumber:
CB69018521
Molecular Formula:
C18H23ClN2O5S
Molecular Weight:
414.9
MDL Number:
MFCD34167537
MOL File:
1838123-22-0.mol
Last updated:2024-07-02 08:55:14
Request For Quotation

Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]- Properties

Boiling point 573.7±50.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 220 mg/mL (530.25 mM; Need ultrasonic)
pka 4.99±0.10(Predicted)
form Solid
color Off-white to light brown

Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]- Chemical Properties,Uses,Production

Biological Activity

(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1].

References

[1]. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.

Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23980 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5012 58
Supplier Advantage
Aladdin Scientific 		58
TargetMol Chemicals Inc. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]- (R,R)-CXCR2-IN-2 (R,R) CXCR2 IN 2,(R,R)CXCR2IN2,(R,R)-CXCR-2-IN-2 1838123-22-0