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ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]-

Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]-

Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]- Structure
Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]- structure
CAS No.
2290608-13-6
Chemical Name:
Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]-
Synonyms
VT103;VT103, 10 mM in DMSO;N-Methyl-3-(1-methyl-1H-imidazol-4-yl)-4-((4-(trifluoromethyl)phenyl)amino)benzenesulfonamide;Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]-
CBNumber:
CB69021479
Molecular Formula:
C18H17F3N4O2S
Molecular Weight:
410.41
MDL Number:
MFCD34567638
MOL File:
2290608-13-6.mol
Last updated:2025-04-17 18:22:24
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Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]- Properties

Boiling point 583.6±60.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (121.83 mM; Need ultrasonic)
pka 11.55±0.50(Predicted)
form Solid
color Off-white to gray

Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]- Chemical Properties,Uses,Production

Uses

VT103, an analog of VT101, is an orally active and selective TEAD1 protein palmitoylation inhibitor. VT103 inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD. VT103 can be used for the research of cancer[1].

Biological Activity

VT103, an analog of VT101, is an orally active and selective TEAD1 protein palmitoylation inhibitor. VT103 inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD. VT103 can be used for the research of cancer[1]. VT103 (HEK293T cells; 3 μM) appeares to be TEAD1-selective, as it does not block palmitoylation of TEAD2, TEAD3, or TEAD4. VT103 (NF2-deficient NCI-H226 cells; 3 mmol/L; 4 or 24 hours) selectively disrupts YAP-TEAD1 interaction[1].VT103 results in the disappearance of palmitoylated TEAD1 with a concomitant increase in unpalmitoylated TEAD1[1]. VT103 (0.3~10 mg/kg; p.o. once per day) blocks tumor growth even at 0.3 mg/kg[1].

in vivo

VT103 (0.3~10 mg/kg; p.o. once per day) blocks tumor growth even at 0.3 mg/kg[1].
Pharmacokinetics of VT103 in mice[1]

DoseIVPO
7 mg/kg T1/2 (hours)Vdss (L/kg)CI(mL/min/kg)AUC 0-24 hours (μg*h/mL)AUC 0-24 hours (μg*h/mL)Oral availability (%)Cmax (ng/mL)C24 hours (ng/mL)
13.24.54.720.014.975896 (1 hour)340
Animal Model:NCI-H226-tumor bearing mice[1]
Dosage:0.3~10 mg/kg
Administration:P.o. once per day
Result:Blocked tumor growth even at 0.3 mg/kg.

References

[1]. Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021;20(6):986-998.

Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]- Suppliers

Global( 23)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Blocksynth Pharmaceutical Technology Co.,Ltd 		0086-19817745290; +8619817745290 bd@blocksynth.com China 5661 58
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 sales@shydchem.com.cn China 990 56
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9330 58
Heze Development Zone chuangli Chemical Co., Ltd. 0530-+86-530-529 6766，+86-15666160102 15666160102 info@chuangli-chem.com China 838 55
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 998 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4348 58
JinOu Biomedical (Nanjing) Co., Ltd. 13000000000 jinoupharma@163.com China 11721 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62072 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Blocksynth Pharmaceutical Technology Co.,Ltd 		58
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
Heze Development Zone chuangli Chemical Co., Ltd. 55
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
ShangHai ChuanQian Chemcial Technique Centre 58
JinOu Biomedical (Nanjing) Co., Ltd. 58
Bide Pharmatech Ltd. 58

View Lastest Price from Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VT103 pictures 2024-11-19 VT103
2290608-13-6
 US $126.00-496.00 / mg 98.73% 10g TargetMol Chemicals Inc.
  • VT103 pictures
  • VT103
    2290608-13-6
  • US $126.00-496.00 / mg
  • 98.73%
  • TargetMol Chemicals Inc.
Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]- VT103 N-Methyl-3-(1-methyl-1H-imidazol-4-yl)-4-((4-(trifluoromethyl)phenyl)amino)benzenesulfonamide VT103, 10 mM in DMSO 2290608-13-6