[S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide
- CAS No.
- 521-40-4
- Chemical Name:
- [S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide
- Synonyms
- narcotoline;Desmethylnarcotine;Cordrastine I;Noscapine Impurity 6(Narcotoline);S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide;[S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide;(3S)-3-[(5R)-4-hydroxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-dimethoxy-3H-2-benzofuran-1-one;(3S)-3-[(5R)-4-hydroxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-dimethoxy-3H-isobenzofuran-1-one;(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one;1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-
- CBNumber:
- CB6905952
- Molecular Formula:
- C21H21NO7
- Molecular Weight:
- 399.39
- MDL Number:
- MOL File:
- 521-40-4.mol
[S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide Properties
Melting point | 202° |
---|---|
alpha | D20 -189° (0.1 g in 25 ml chloroform, 20 cm tube); D20 +5.8° (0.065 g in 5 ml 0.1N HCl in 20 cm tube) |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
color | Pale Yellow to Light Yellow |
FDA UNII | M5V1K1QE3F |
[S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide price
[S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide Chemical Properties,Uses,Production
Description
Wrede has obtained this alkaloid from the seed capsules of Papaver somniferum. It crystallizes from aqueous MeOH in colourless rectangular rods and has [0:]5° - 189° (CHCI3) and + 5.8° (c 0.1 NiHCI). One phenolic hydroxyl group is present in the molecule and the base forms the O-acetate, m.p. 208-9°C, giving a hydro_x0002_chloride as the monohydrate, m.p. 230-3°C (dry); [0:]5° + 94.8° (H 20). The acid tartrate forms colourless needles which, decompose at 190-205°C and the picrolonate has m.p. 202-3°C. On treatment with CH2N2, the alkaloid gives Narcotine (q.v.).
Uses
Desmethylnarcotine is an impurity of Narcotoline an opiate alkaloid and a structure analogue of Nascapine (N882000), an antitussive agent. Noscapine (N882000) metabolite.
Definition
ChEBI: Narcotoline is a member of isoquinolines.
References
Wrede., r;hem. Zentr., I, 2611 (1937)
Wrede., ibid, II, 863 (1938)
[S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9911 | 50 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Shaanxi Dideu Medichem Co. Ltd | 029-61856358 15229202216 | 1020@dideu.com | China | 10011 | 58 |
Chengdu Push Bio-Technology Co., Ltd. | 18080489829 | 3004654993@qq.com | China | 9209 | 58 |
Supplier | Advantage |
---|---|
Hubei Jusheng Technology Co.,Ltd. | 58 |
Shanghai Kewel Chemical Co., Ltd. | 50 |
Energy Chemical | 58 |
Shaanxi Dideu Medichem Co. Ltd | 58 |
Chengdu Push Bio-Technology Co., Ltd. | 58 |