6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride
- CAS No.
- 91574-89-9
- Chemical Name:
- 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride
- Synonyms
- 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride
- CBNumber:
- CB6927710
- Molecular Formula:
- C27H32ClNO3
- Molecular Weight:
- 454.00088
- MDL Number:
- MOL File:
- 91574-89-9.mol
6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride Properties
FDA UNII | 8VX5A020BS |
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6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride Chemical Properties,Uses,Production
Originator
Asocainol,ZYF Pharm
Manufacturing Process
A solution of a Grignard reagent is prepared from 5.5 g (0.23 mol) activated magnesium turnings and 41.5 g (0.24 mol) phenethyl bromide in 200 ml anhydrous diethyl ether. To this is added dropwise, at 35-40°C, a solution of 31.5 g (0.1 mol) thebaine in 0.4 liters dry benzene. After heating under reflux for 2 hours, the reaction mixture is decomposed with a solution of 48 g ammonium chloride in 200 ml water. The usual working up, after conversion of the base into the hydrochloride by means of hydrogen chloride in ethyl acetate, gives 7.3 g (21% of theory) (+/-)-2,12-dimethoxy-1-hydroxy-7- methyl-6-phenethyl-5,6,8,9-tetrahydro-7H-dibenz[d,f]azonine hydrochloride, melting point 227.6°C, after recrystallization from propan-2-ol.
Therapeutic Function
Antiarrhythmic
6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride Preparation Products And Raw materials
6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz[d,f]azonin-1-ol hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28070 | 58 |
Supplier | Advantage |
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TargetMol Chemicals Inc. | 58 |