ChemicalBook >> CAS DataBase List >>2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-

2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-

2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]- structure

CAS No.: 1917306-14-9

Chemical Name:: 2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-

Synonyms: tert-butyl (3R;4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate;2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-

CBNumber:: CB69376032

Molecular Formula:: C23H23Cl2F6N3O4S

Molecular Weight:: 622.41

MDL Number:

MOL File:: 1917306-14-9.mol

Last updated:2024-07-02 08:55:14

Request For Quotation

2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]- Properties

Density	1.494±0.06 g/cm3(Predicted)
pka	4.85±0.46(Predicted)
form	Solid
color	White to off-white

2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]- Chemical Properties,Uses,Production

Description

JNJ-61803534 is a novel potent RORγt inverse agonist, selectively inhibiting RORγt-driven transcription versus closely-related family members, RORα and RORβ, also inhibiting IL-17A production in human CD4+ T cells under Th17 differentiation conditions, but not inhibiting IFNγ production under Th1 differentiation conditions, and having neither impact on in vitro differentiation of regulatory T cells (Treg), nor on the suppressive activity of natural Tregs.

2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]- Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3453	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4217	55
Shanghaizehan biopharma technology co., Ltd.	021-61350663 13052117465	sales@zehanbiopharma.com	China	1000	55
Wuxi Donghe Pharmaceutical Technology Co., Ltd.	63313187 15358055255	63313187@qq.com	China	1972	58
Wuhan Acumen Bio-Technology Co.,ltd	027-027-16602739303 16602739303	673003916@qq.com	China	3063	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28118	58

Supplier	Advantage
Aladdin Scientific	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghaizehan biopharma technology co., Ltd.	55
Wuxi Donghe Pharmaceutical Technology Co., Ltd.	58
Wuhan Acumen Bio-Technology Co.,ltd	58
TargetMol Chemicals Inc.	58

2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]- 4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate tert-butyl (3R 1917306-14-9 C23H23Cl2F6N3O4S