3-Quinolinecarboxylic acid, 6-[[(2S)-2-[([1,1'-biphenyl]-4-ylcarbonyl)amino]-1-oxopropyl]amino]-1,4-dihydro-4-oxo-
- CAS No.
- 2580935-57-3
- Chemical Name:
- 3-Quinolinecarboxylic acid, 6-[[(2S)-2-[([1,1'-biphenyl]-4-ylcarbonyl)amino]-1-oxopropyl]amino]-1,4-dihydro-4-oxo-
- Synonyms
- PTPN22-IN-1; (S)-6-(2-([1,1'-biphenyl]-4-ylcarboxamido)propanamido)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 6-[[(2S)-2-[([1,1'-biphenyl]-4-ylcarbonyl)amino]-1-oxopropyl]amino]-1,4-dihydro-4-oxo-
- CBNumber:
- CB69824306
- Molecular Formula:
- C26H21N3O5
- Molecular Weight:
- 455.46
- MDL Number:
- MOL File:
- 2580935-57-3.mol
3-Quinolinecarboxylic acid, 6-[[(2S)-2-[([1,1'-biphenyl]-4-ylcarbonyl)amino]-1-oxopropyl]amino]-1,4-dihydro-4-oxo- Chemical Properties,Uses,Production
Biological Activity
PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 μM; Ki=0.50 μM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses[1]. From WO2021007491A1 compound L-1. PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects[1].Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 μM h and Cmax of 1.1 1 μM (Fig. 9d), which is more than twice of its Ki value[1]. PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects[1].Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 μM h and Cmax of 1.1 1 μM (Fig. 9d), which is more than twice of its Ki value[1].
References
[1]. Elizabeth Jaffee, et al. Targeting ptpn22 in cancer therapy. WO2021007491A1.
3-Quinolinecarboxylic acid, 6-[[(2S)-2-[([1,1'-biphenyl]-4-ylcarbonyl)amino]-1-oxopropyl]amino]-1,4-dihydro-4-oxo- Preparation Products And Raw materials
Raw materials
Preparation Products
3-Quinolinecarboxylic acid, 6-[[(2S)-2-[([1,1'-biphenyl]-4-ylcarbonyl)amino]-1-oxopropyl]amino]-1,4-dihydro-4-oxo- Suppliers
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TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
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TargetMol Chemicals Inc. | 58 |