ChemicalBook >> CAS DataBase List >>1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl-

1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl-

1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- structure

CAS No.: 393129-91-4

Chemical Name:: 1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl-

Synonyms: WAY-388264-A;5-HT2B antagonist-1;WAY388264A,WAY 388264 A;1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl-;4-(4-((4-(tert-Butyl)phenyl)sulfonyl)piperazin-1-yl)-5,6-dimethylthieno[2,3-d]pyrimidine

CBNumber:: CB710722386

Molecular Formula:: C11H14BrN5

Molecular Weight:: 296.17

MDL Number:

MOL File:: 393129-91-4.mol

Last updated:2024-07-02 08:55:14

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1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- Properties

Melting point	137 °C
Boiling point	382.0±44.0 °C(Predicted)
Density	1.60±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	9.96±0.40(Predicted)
form	Solid
color	White to off-white

1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- Chemical Properties,Uses,Production

Biological Activity

5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2]. 5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC50 values in the range of 12.6 to 57.5 μM[1].5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines[3]. 5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) can reduce visceral hypersensitivity significantly in irritable bowel syndrome (IBS) rats[2].

References

[1]. Xiang Ma, et al. Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5644[2]. Yu Zhou, et al. Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome. J Med Chem. 2016 Jan 28;59(2):707-20.[3]. Huang Niu, et al. 5-HT2B Antagonists. WO2015158214

1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- Preparation Products And Raw materials

Raw materials

Preparation Products

1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3770	55
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	63720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5012	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	+86-18521732826	market@aladdin-e.com	China	48466	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

Supplier	Advantage
Aladdin Scientific	58
Tianjin Kailiqi Biotechnology Co., Ltd.	55
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58
TargetMol Chemicals Inc.	58

WAY-388264-A 1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- WAY388264A,WAY 388264 A 4-(4-((4-(tert-Butyl)phenyl)sulfonyl)piperazin-1-yl)-5,6-dimethylthieno[2,3-d]pyrimidine 5-HT2B antagonist-1 393129-91-4