7-Deaza-2'-C-methyladenosine
- CAS No.
- 443642-29-3
- Chemical Name:
- 7-Deaza-2'-C-methyladenosine
- Synonyms
- MK-608;MK-0608;Lamevudine;7-deaza-2C-Me-A;2'--C-Meth yltubercidin;2'-b-C-methyl tubercidin;7-Deaza-2'-C-methyladenosine;7-Deaza-2'-C-Methyladenosine;7H-PYRROLO[2,3-D]PYRIMIDIN-4-A;2’-b-C-Methyl-7-deazaadenosine
- CBNumber:
- CB71074003
- Molecular Formula:
- C12H16N4O4
- Molecular Weight:
- 280.28
- MDL Number:
- MFCD14584964
- MOL File:
- 443642-29-3.mol
Melting point | 222 °C(Solv: methanol (67-56-1); acetonitrile (75-05-8)) |
---|---|
Boiling point | 620.7±55.0 °C(Predicted) |
Density | 1.75±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
pka | 12.51±0.70(Predicted) |
form | Solid |
color | White to off-white |
InChI | InChI=1/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/s3 |
InChIKey | IRZRJANZDIOOIF-ULJXVLPWNA-N |
SMILES | C[C@]1([C@@H]([C@@H](CO)O[C@H]1N1C=CC2=C(N=CN=C12)N)O)O |&1:1,2,3,7,r| |
FDA UNII | QRR62J6WEF |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
7-Deaza-2'-C-methyladenosine price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML3200 | MK-0608 ≥98% (HPLC) | 443642-29-3 | 5MG | $112 | 2024-03-01 | Buy |
Sigma-Aldrich | SML3200 | MK-0608 ≥98% (HPLC) | 443642-29-3 | 25MG | $360 | 2024-03-01 | Buy |
TRC | D201650 | 7-Deaza-2''-C-methyladenosine | 443642-29-3 | 25mg | $160 | 2021-12-16 | Buy |
TRC | D201650 | 7-Deaza-2''-C-methyladenosine | 443642-29-3 | 100mg | $605 | 2021-12-16 | Buy |
Biosynth Carbosynth | ND08351 | 7-Deaza-2'-C-methyladenosine | 443642-29-3 | 10mg | $85 | 2021-12-16 | Buy |
7-Deaza-2'-C-methyladenosine Chemical Properties,Uses,Production
Uses
7-Deaza-2''-C-methyladenosine is a hepatitis C virus (HCV) polymerase inhibitor.
Definition
MK 0608 (7-Deaza-2'-C-methyladenosine) is an anti-viral agent against Hepatitis C Virus (HCV). It has been shown to inhibit viral RNA replication in the subgenomic HCV genotype 1b replicon, with a 50% effective concentration (EC50) of 0.3 μM (EC90 = 1.3 μM). To determine efficacy in vivo, MK-0608 was administered to HCV-infected chimpanzees, resulting in dose- and time-dependent decreases in plasma viral loads. In separate experiments, chimpanzees dosed for 7 days with MK-0608 at 0.2 and 2 mg per kg of body weight per day by intravenous administration experienced average reductions in viral load of 1.0 and >5 log10 IU/ml, respectively.
Solubility in organics
Soluble in DMSO, not in water.
storage
Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
7-Deaza-2'-C-methyladenosine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD | 0371-55159968 18137130222 | haifeng.zhang@pannacean.com | China | 527 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29899 | 58 |
Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9980 | 58 |
changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9740 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 |
View Lastest Price from 7-Deaza-2'-C-methyladenosine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-08-06 | Lamevudine
443642-29-3
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
- Lamevudine
443642-29-3
- US $5.00 / KG
- 99%
- Career Henan Chemical Co