ChemicalBook >> CAS DataBase List >>4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1)

4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1)

4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1) structure

CAS No.: 2095064-09-6

Chemical Name:: 4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1)

Synonyms: (R)-Posenacaftor sodium;(R)Posenacaftor sodium,(R) Posenacaftor sodium;4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1)

CBNumber:: CB711018251

Molecular Formula:: C27H28NNaO5

Molecular Weight:: 469.51

MDL Number:

MOL File:: 2095064-09-6.mol

Last updated:2024-07-02 08:55:14

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4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1) Properties

storage temp.	Store at -20°C
solubility	DMSO : 38.33 mg/mL (81.99 mM; Need ultrasonic)
form	Solid
color	Yellow to brown

4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1) Chemical Properties,Uses,Production

Biological Activity

(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF)[1]. Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR)[1].CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells. Mutations in the CFTR gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells[1].Posenacaftor is a CFTR corrector, correctors are designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways[2].

References

[1]. Benjamin Kopp, et al. Compositions et procédés pour améliorer la fonction cftr dans des cellules affectées par la fibrose kystique. Patent WO2019156946.

4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1) Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9282	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
RD International Technology Co., Limited	58

4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethoxy]-, sodium salt (1:1) (R)-Posenacaftor sodium (R)Posenacaftor sodium,(R) Posenacaftor sodium 2095064-09-6 C27H28NNaO5