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GRL-0667

GRL-0667 structure

CAS No.: 1234195-91-5

Chemical Name:: GRL-0667

Synonyms: GRL-0667

CBNumber:: CB711047147

Molecular Formula:: C26H28N2O3

Molecular Weight:: 416.52

MDL Number:

MOL File:: 1234195-91-5.mol

Last updated:2023-05-04 17:34:32

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GRL-0667 Properties

storage temp.	-20°C
solubility	Soluble in DMSO (>25 mg/ml) or ethanol (15 mg/ml)
form	solid
color	Off-white
Stability	Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

GRL-0667 Chemical Properties,Uses,Production

Description

GRL-0667 (1234195-91-5) is a potent (IC50 = 320 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). GRL-0667 inhibited SARS-CoV viral replication in Vero E6 cells with no cytotoxicity (EC50 = 9.1 μM).1

Definition

ChEBI: N-(1,3-Benzodioxol-5-Ylmethyl)-1-[(1r)-1-Naphthalen-1-Ylethyl]piperidine-4-Carboxamide is a member of naphthalenes. It has a role as an anticoronaviral agent.

References

Ghosh et al. (2010), Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Novel Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation; J. Med. Chem. 53 4968

GRL-0667 Preparation Products And Raw materials

Raw materials

Preparation Products

GRL-0667 Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Focus Biomolecules	--	sales@focusbiomolecules.com	United States	1284	58

Supplier	Advantage
Focus Biomolecules	58

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GRL-0667 1234195-91-5