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ChemicalBook >> CAS DataBase List >>2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)-

2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)-

2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- Structure
2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- structure
CAS No.
2582816-37-1
Chemical Name:
2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)-
Synonyms
2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)-
CBNumber:
CB711920648
Molecular Formula:
C19H14FN5OS
Molecular Weight:
379.41
MDL Number:
MOL File:
2582816-37-1.mol
Last updated:2024-10-23 13:36:13
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2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- Properties

Boiling point 672.1±65.0 °C(Predicted)
Density 1.54±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 10.81±0.29(Predicted)
color Light yellow to yellow

2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- Chemical Properties,Uses,Production

Biological Activity

XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases[1].

References

[1]. Li Z, et al. Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo. J Med Chem. 2020;63(8):4388-4407.

2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19884 58
Suzhou Haiben Pharmaceutical Co., Ltd 14760821013 13564957716 1816280386@qq.com China 8045 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 4997 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19703 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 18013972705 qqyang@aikonchem.com China 10238 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Suzhou Haiben Pharmaceutical Co., Ltd 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
TargetMol Chemicals Inc. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58

View Lastest Price from 2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
XT2 pictures 2024-10-24 XT2
2582816-37-1
 US $2190.00-3520.00 / mg 10g TargetMol Chemicals Inc.
  • XT2 pictures
  • XT2
    2582816-37-1
  • US $2190.00-3520.00 / mg
  • TargetMol Chemicals Inc.
2-Thiazolemethanol, α-[2-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]ethynyl]-α-methyl-, (αR)- 2582816-37-1