Netilmicin sulfate | 56391-57-2

Netilmicin sulfate Properties

Melting point	>194°C (dec.)
Boiling point	868℃
storage temp.	Inert atmosphere,2-8°C
solubility	H2O: soluble10mg/mL
form	Solid
color	white to faint yellow
Water Solubility	Soluble in water
Sensitive	Light Sensitive & Hygroscopic
Stability	Hygroscopic
FDA UNII	S741ZJS97U
Proposition 65 List	Netilmicin Sulfate
EPA Substance Registry System	Netilmicin sulfate (56391-57-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Danger

Hazard statements

H360

Precautionary statements

P201-P202-P280-P308+P313-P405-P501

Hazard Codes

T,Xi

Risk Statements

61-20/21/22-60

Safety Statements

53-36/37/39-45-37/39-36-26

WGK Germany

3

RTECS

WK2286000

HS Code

2941906000

NFPA 704

	0
3		0

Netilmicin sulfate price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001890	Netilmicin for peak identification European Pharmacopoeia (EP) Reference Standard	56391-57-2	Y0001890	$150	2024-03-01	Buy
Sigma-Aldrich	N0755	Netilmicin sulfate salt	56391-57-2	5mg	$301.2	2024-03-01	Buy
Sigma-Aldrich	1460500	Netilmicin sulfate	56391-57-2	500mg	$436	2024-03-01	Buy
TCI Chemical	N1108	Netilmicin Sulfate >98.0%(HPLC)	56391-57-2	25mg	$16	2024-03-01	Buy
TCI Chemical	N1108	Netilmicin Sulfate >98.0%(HPLC)	56391-57-2	100mg	$48	2024-03-01	Buy

Product number	Packaging	Price	Buy
Y0001890	Y0001890	$150	Buy
N0755	5mg	$301.2	Buy
1460500	500mg	$436	Buy
N1108	25mg	$16	Buy
N1108	100mg	$48	Buy

Netilmicin sulfate Chemical Properties,Uses,Production

Description

Netilmicin Sulfate is the sulfate salt form of netilimicin, a member of the aminoglycoside family of antibiotics. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. It is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin.

Chemical Properties

Off-White to Pale Beige Solid

Uses

Netilmicin sulfate is used as a broad spectrum antibiotic active against most Gram-negative and some Gram-positive bacteria. It is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but has less ear and kidney toxicity. It is used to treat gram-negative bacterial infections, gonorrhea, skin infections, and other infectious diseases. Since netilmicin sulfate cannot be absorbed from the gut, it can only be administered by injection.

Definition

ChEBI: Netilmicin sulfate is an aminoglycoside sulfate salt. It is functionally related to a netilmycin.

Application

Netilmicin was synthesized by ScheringPlough Co. in 1976. The ethyl moiety was introduced at the 1-amino group of sisomicin. Its design was based on an understanding of the biochemical mechanisms of bacterial resistance to the gentamicin – sisomicin antibiotic group. The modification at the 1-amino group is known to prevent adenylation at the 2- hydroxyl group and acetylation at the 3-amino group, and to deter acetylation at the 6 -amino residue. Netilmicin shows almost the same activity against a variety of gram-positive and gram-negative bacteria as sisomicin and strong activity against gentamicin – sisomicin-resistant bacteria. It is now under study for evaluation of its clinical efficacy and safety.

Clinical Use

Netilmicin sulfate, 1-N-ethylsisomicin (Netromycin), is asemisynthetic derivative prepared by reductive ethylation138of sisomicin, an aminoglycoside antibiotic obtained fromMicromonospora inyoensis. Structurally, sisomicin andnetilmicin resemble gentamicin Cla, a component of the gentamicincomplex.
Against most strains of Enterobacteriaceae, P. aeruginosa,and S. aureus, sisomicin and netilmicin are comparableto gentamicin in potency. Netilmicin is active, however,against many gentamicin-resistant strains, in particularamong E. coli, Enterobacter, Klebsiella, and Citrobacterspp. A few strains of gentamicin-resistant P. aeruginosa, S.marcescens, and indole-positive Proteus spp. are also sensitiveto netilmicin. Very few gentamicin-resistant bacterialstrains are sensitive to sisomicin, however. The potency ofnetilmicin against certain gentamicin-resistant bacteria is attributedto its resistance to inactivation by bacterial enzymesthat adenylylate or phosphorylate gentamicin and sisomicin.Evidently, the introduction of a 1-ethyl group in sisomicinmarkedly decreases the affinity of these enzymes forthe molecule in a manner similar to that observed in the1-N-ε-amino-α-hydroxybutyryl amide of kanamycin A(amikacin). Netilmicin, however, is inactivated by most of the bacterial enzymes that acetylate aminoglycosides,whereas amikacin is resistant to most of these enzymes.
The pharmacokinetic and toxicological properties ofnetilmicin and gentamicin appear to be similar clinically,though animal studies have indicated greater nephrotoxicityfor gentamicin.

Netilmicin sulfate Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Copper(II) acetate Ethanol Cupric acetate monohydrate

Preparation Products

Netilmicin sulfate Suppliers

Global( 261)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8618959220845	sales@amoychem.com	China	6383	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Qiuxian Baitai New Material Co., LTD	+8618330912755	sale2@hbyalin.com	China	1658	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Qiuxian Baitai New Material Co., LTD	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from Netilmicin sulfate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Netilmicin sulfate 56391-57-2	US $51.00-140.00 / mg		99.83%	10g	TargetMol Chemicals Inc.
2024-11-19	Netilmicin sulfate 56391-57-2	US $51.00-140.00 / mg		99.83%	10g	TargetMol Chemicals Inc.
2021-11-15	Netilmicin sulfate 56391-57-2	US $80.00 / KG	10g	99%	500ton/Month	Qiuxian Baitai New Material Co., LTD

Netilmicin sulfate
56391-57-2
US $51.00-140.00 / mg
99.83%
TargetMol Chemicals Inc.

Netilmicin sulfate
56391-57-2
US $51.00-140.00 / mg
99.83%
TargetMol Chemicals Inc.

Netilmicin sulfate
56391-57-2
US $80.00 / KG
99%
Qiuxian Baitai New Material Co., LTD

Netilmicin sulfate Spectrum

Netilmicin sulfate(56391-57-2)MS

56391-57-2(Netilmicin sulfate )Related Search:

Copper(II) sulfate Sisomicin Aluminum sulfate 3-Aminophenol Glycine

Barium sulfate Sodium thiosulfate Zinc sulfate heptahydrate ALTRENOGEST Ammonium sulfate

Tris(hydroxymethyl)aminomethane Ferrous sulfate heptahydrate Vanadyl sulfate NETILMICIN 6-Aminocaproic acid

Magnesium sulfate heptahydrate Sodium sulfate sulfate

1of4

D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-N1-ethyl-, sulfate (2:5) Netilmicin sulfhate Netilmicin sulfate(2:5) Netilmicin sulphate, 1-N-Ethylsisomicin 6-diamino-2,3,4,6-tetradeoxy-alpha-d-glycero-hex-4-enopyranosyl-(1-4)-6)-o-( sulfate(2:5)(salt) Sulfate NetilMicin (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4-amino-3-[[(2s,3r)-3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy]-6-ethylamino-2-hydroxycyclohexyl]oxy-5-methyl-4-methylaminooxane-3,5-diol sulfate (2:5) Netilmicin Sulfate (500 mg) O-3-Deoxy-4-C-Methyl-3-(MethylaMino)-β-l-arabinopyranosyl-(1-6)-O-[2,6-diaMino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N'-ethyl-D-streptaMine Netilmicin Sulfate Usp Netililn O-3-Deoxy-4-C-methyl-3-(methylamino)-b-l-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-Nethyl-D-streptamine D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(14)]-2-deoxy-N1-ethyl-, sulfate (2:5) (salt) (9CI) Zetamicin Netilmicin sulfate (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-Amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-ethylamino-2-hydroxycyclohexyl]oxy-5-methyl-4-methylaminooxane-3,5-diol sulfate (2:5) O-3-Deoxy-4-C-methyl-3-methylamino-ss-L-arabinopyranosyl-(1->6)-O-[2, 6-diamino-4,5-dehydro-2,3,4,6-tetradeoxy-a-D-glycero-hexopyranosyl-(1->4)]-2-deoxy-1-N-ethyl-D-streptamine hemiheptasulfate O-3-Deoxy-4-C-methyl-3-(methylamino)--l-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N’-ethyl-D-streptamine 4-O-[[3α-Amino-6-(aminomethyl)-3,4-dihydro-2H-pyran]-2α-yl]-6-O-[4-C-methyl-3-(methylamino)-3-deoxy-β-L-arabinopyranosyl]-N1-ethyl-2-deoxy-D-streptamine·2.5sulfuric acid Netromycin sulfate Netilmicin sulfate salt,1-N-Ethylsisomicin 1-N-ETHYLSISOMICIN 1-N-ETHYLSISOMICIN SULFATE O-3-DEOXY-4-C-METHYL-3-METHYLAMINO-BETA-L-ARABINOPYRANOSYL-(1->6)-O-[2, 6-DIAMINO-4,5-DEHYDRO-2,3,4,6-TETRADEOXY-A-D-GLYCERO-HEXOPYRANOSYL-(1->4)]-2-DEOXY-1-N-ETHYL-D-STREPTAMINE HEMIHEPTASULFATE NETILMICIN SULFATE NETILMICIN SULFATE SALT NETILMYCIN SULPHATE NETILMICIN SULFATE USP EP NETILMYCIN SULFATE USP27 O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N1-ethyl-D-streptamine sestersulfate Netilmicin Impurity Netilmicin for peak identification Netilmicin sulfate CRS SCH-20569 (sulfate) (2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4-Amino-3-(((2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl)oxy)-6-(ethylamino)-2-hydroxycyclohexyl)oxy)-5-methyl-4-(methylamino)tetrahydro-2H-pyran-3,5-diol sulfate(2:5) Netilmicin sulfate USP/EP/BP Netilmicin Sulfate (SCH-20569) Netilmicin Sulphate (NTC Sulphate), 595ug/mg Netilmicin Sulfate (1460500) netromycin Netromicine NETILMYCIN SULFATE Netilimicin (sulfate) Netilmicin for peak identification CRS/C1A Netilmicin sulfate for LC assay CRS/C1A 56391-57-2 C42H92N10O34S5 2C21H41N5O75H2SO4 C21H41N5O752H2SO4 C21H41N5O725H2SO4 C42H92N10O34S5C21H41N5O7freebase C21H41N5O7H2SO4 C21H41N5O725H2O4S 2C21H41N5O75H2O4S C21H41N5O7212H2SO4 BioChemical Antibiotics A to Z Antibiotics