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ChemicalBook >> CAS DataBase List >>2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-

2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-

2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- Structure
2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- structure
CAS No.
2413940-56-2
Chemical Name:
2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-
Synonyms
NF-κB/MAPK-IN-1;NF-κB/MAPK-IN-1, 10 mM in DMSO;2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-
CBNumber:
CB712311991
Molecular Formula:
C27H27NO7
Molecular Weight:
477.51
MDL Number:
MOL File:
2413940-56-2.mol
Last updated:2025-04-28 21:36:36
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2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- Properties

Boiling point 677.4±55.0 °C(Predicted)
Density 1.225±0.06 g/cm3(Predicted)
pka 12.23±0.70(Predicted)
form Solid
color Light yellow to yellow

2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- Chemical Properties,Uses,Production

Uses

NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 μM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1].

IC 50

NF-κB; p38; COX-2

References

[1] Hu YS, et al. Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. Bioorg Chem. 2020 May;98:103735. DOI:10.1016/j.bioorg.2020.103735

2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32265 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6389 55
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 5003 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19930 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 48813 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Jinan Jiuli Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58

View Lastest Price from 2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NF-κB/MAPK-IN-1 pictures 2025-04-27 NF-κB/MAPK-IN-1
2413940-56-2
 US $55.00-156.00 / mg 97.03% 10g TargetMol Chemicals Inc.
  • NF-κB/MAPK-IN-1 pictures
  • NF-κB/MAPK-IN-1
    2413940-56-2
  • US $55.00-156.00 / mg
  • 97.03%
  • TargetMol Chemicals Inc.
2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- NF-κB/MAPK-IN-1 NF-κB/MAPK-IN-1, 10 mM in DMSO 2413940-56-2