ChemicalBook >> CAS DataBase List >>(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid structure

CAS No.: 914804-63-0

Chemical Name:: (Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid

Synonyms: 8-iso-15-keto-PGE2;Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,8β,11α,13E)-;(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid;(Z)-7-((1S,2R,3R)-3-hydroxy-5-oxo-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid

CBNumber:: CB71235657

Molecular Formula:: C20H30O5

Molecular Weight:: 350.45

MDL Number:: MFCD05863945

MOL File:: 914804-63-0.mol

Last updated:2023-06-08 09:03:09

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(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid Properties

Boiling point	534.4±50.0 °C(Predicted)
Density	1.144±0.06 g/cm3(Predicted)
solubility	DMF: 33 mg/ml; DMSO: 20 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 1.4 mg/ml
pka	4.75±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H319-H336

Precautionary statements

P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501

NFPA 704

	3
2		0

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	14390	8-iso-15-keto Prostaglandin E2 ≥98%	914804-63-0	100μg	$21	2024-03-01	Buy
Cayman Chemical	14390	8-iso-15-keto Prostaglandin E2 ≥98%	914804-63-0	500μg	$89	2024-03-01	Buy
Cayman Chemical	14390	8-iso-15-keto Prostaglandin E2 ≥98%	914804-63-0	1mg	$157	2024-03-01	Buy
Cayman Chemical	14390	8-iso-15-keto Prostaglandin E2 ≥98%	914804-63-0	5mg	$680	2024-03-01	Buy

Product number	Packaging	Price	Buy
14390	100μg	$21	Buy
14390	500μg	$89	Buy
14390	1mg	$157	Buy
14390	5mg	$680	Buy

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid Chemical Properties,Uses,Production

Description

8-iso-15-keto Prostaglandin E₂ (8-iso-15-keto PGE₂) is an isoprostane, one member of a large family of biomarkers produced by the free radical peroxidative degradation of membrane lipids.¹ 8-iso-15-keto PGE₂ is the theoretical first metabolite of 8-iso PGE₂ via the 15-hydroxy PGDH pathway. While a number of potent biological activities have been attributed to 8-iso PGE₂,² there are no published reports at this time regarding its metabolism.

Definition

ChEBI: 8-iso-15-keto-PGE2 is a prostanoid.

References

1. Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism Proc. Natl. Acad. Sci. USA 87(23),9383-9387(1990).
2. Longmire, A.W., Roberts, L.J., and Morrow, J.D. Actions of the E₂-isoprostane, 8-iso-PGE₂, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor Prostaglandins 48,247-256(1994).

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid Suppliers

Global( 6)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1990	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58

Supplier	Advantage
Shanghai Hongye Biotechnology Co. Ltd	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid 8-iso-15-keto-PGE2 (Z)-7-((1S,2R,3R)-3-hydroxy-5-oxo-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,8β,11α,13E)- 914804-63-0