ignavine

CAS No.
1357-76-2
Chemical Name:
ignavine
Synonyms
ignavine;Hetisan-2α,3β,9,15β-tetrol 2-benzoate;Hetisan-2,3,9,15-tetrol, 2-benzoate, (2α,3β,15β)- (9CI)
CBNumber:
CB71342456
Molecular Formula:
C27H31NO5
Molecular Weight:
449.54
MDL Number:
MOL File:
1357-76-2.mol

ignavine Properties

Melting point 226-8°C

SAFETY

Risk and Safety Statements

Toxicity LD50 oral in mouse: > 500mg/kg

ignavine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation PXT0004867 IGNAVINE 95.00% 1357-76-2 5MG $503.36 2021-12-16 Buy
Product number Packaging Price Buy
PXT0004867 5MG $503.36 Buy

ignavine Chemical Properties,Uses,Production

Description

This aconitine alkaloid is present in several A conitum species indigenous to Japan, e.g. Aconitum calliantum Koidzumi, A. grossedentatum, Nakai, A. hakusanense Nakai, A. kamtschaticum Willd. et Reichb., A. lucidusculum Nakai, A. senanense Nakai, A. subcuneatum Nakai, A. tortuosum Willd. and A. Zuccarini Nakai. It yields clusters of colourless needles when crystallized from Me2COMeOH and gives a form, m.p. 172-4 °c in addition to the one having the above melting point. It is dextrorotatory with [α]29D~} + 85.27° (MeOH), or [α]14D + 92.98°. Crystalline salts of the alkaloid have been prepared, e.g. the hydrochloride, m.p. 245-6°C (dec.); hydrobromide, m.p. 260-2°C (dec.) and the nitrate which crystallizes as the monohydrate, m.p. 220-2°C (dec. dry). Alkaline hydrolysis furnishes benzoic acid and hydroignavinol, C20H2S04N, m.p. 302°C.

References

Ochiai et al., J. Pharm. Soc., Japan, 72, 816 (1952) Ochiai et al., ibid, 76, 550 (1956) Ochiai", Okamoto, Sasaki., ibid, 75,545 (1955) Ochiai et al., Chem. Pharm. Bull., 6,327 (1958) Ochiai et al., ibid, 8, 976 (1960) Pelletier., Tetrahedron, 14,103 (1961)

ignavine Preparation Products And Raw materials

Raw materials

Preparation Products

ignavine Hetisan-2α,3β,9,15β-tetrol 2-benzoate Hetisan-2,3,9,15-tetrol, 2-benzoate, (2α,3β,15β)- (9CI) 1357-76-2